Cargando…

Simulated Cytoskeletal Collapse via Tau Degradation

We present a coarse-grained two dimensional mechanical model for the microtubule-tau bundles in neuronal axons in which we remove taus, as can happen in various neurodegenerative conditions such as Alzheimers disease, tauopathies, and chronic traumatic encephalopathy. Our simplified model includes (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sendek, Austin, Fuller, Henry R., Hayre, N. Robert, Singh, Rajiv R. P., Cox, Daniel L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146510/ https://www.ncbi.nlm.nih.gov/pubmed/25162587 http://dx.doi.org/10.1371/journal.pone.0104965

Ejemplares similares

Semisynthesis reveals apoptin as a tumour-selective protein prodrug that causes cytoskeletal collapse
por: Wyatt, Jasmine, et al.
Publicado: (2023)

Rare presentation of collapse and cardiomyopathy in phaeochromocytoma
por: Singh, Rajiv, et al.
Publicado: (2021)

Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network
por: Sonawane, Shweta Kishor, et al.
Publicado: (2021)

Coupled local translation and degradation regulate growth cone collapse
por: Deglincerti, Alessia, et al.
Publicado: (2015)

Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies
por: Yan, Wen, et al.
Publicado: (2022)

Surgical Reconstruction of Progressive Collapsing Foot Deformity Restores Kinematics during Simulated Level Walking
por: Henry, Jensen K., et al.
Publicado: (2022)

Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates cytoskeletal network in neuronal cells
por: Dubey, Tushar, et al.
Publicado: (2020)

Tau interferes with axonal neurite stabilization and cytoskeletal composition independently of its ability to associate with microtubules
por: Boumil, Edward F., et al.
Publicado: (2020)

TGF-β1 signalling in Alzheimer’s pathology and cytoskeletal reorganization: a specialized Tau perspective
por: Kapoor, Mahima, et al.
Publicado: (2023)

Cytoskeletal protein degradation in brain death donor kidneys associates with adverse posttransplant outcomes
por: Vaughan, Rebecca H., et al.
Publicado: (2022)

The Impact of Progressive Collapsing Foot Deformity on Foot & Ankle Kinematics and Plantar Pressure During Simulated Gait
por: Henry, Jensen K., et al.
Publicado: (2022)

Colony Collapse Disorder in context
por: Williams, Geoffrey R, et al.
Publicado: (2010)

Usp14 Deficiency Increases Tau Phosphorylation without Altering Tau Degradation or Causing Tau-Dependent Deficits
por: Jin, Youngnam N., et al.
Publicado: (2012)

Ao and Ho -> tau tau : full simulation
por: Cavalli, D, et al.
Publicado: (1993)

Much More Than a Cytoskeletal Protein: Physiological and Pathological Functions of the Non-microtubule Binding Region of Tau
por: Brandt, Roland, et al.
Publicado: (2020)

Author Correction: Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates cytoskeletal network in neuronal cells
por: Dubey, Tushar, et al.
Publicado: (2022)

Adhesion of Active Cytoskeletal Vesicles
por: Maan, Renu, et al.
Publicado: (2018)

Lysine acetylation of cytoskeletal proteins: Emergence of an actin code
por: A, Mu, et al.
Publicado: (2020)

Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity
por: Lee, Jung Hoon, et al.
Publicado: (2015)

Psychiatric Consequences of WTC Collapse and The Gulf War*
por: Singh, Ajai R., et al.
Publicado: (2004)

Collapse of Insect Gut Symbiosis under Simulated Climate Change
por: Kikuchi, Yoshitomo, et al.
Publicado: (2016)

Analytical Simulation of the Microbubble Collapsing in a Welding Fusion Pool
por: Teyeb, Ahmed, et al.
Publicado: (2023)

Organized collapse
por: Kozlov, Dmitry N
Publicado: (2020)

Targeting tauopathy with engineered tau-degrading intrabodies
por: Gallardo, Gilbert, et al.
Publicado: (2019)

α-Actinin-4-Mediated FSGS: An Inherited Kidney Disease Caused by an Aggregated and Rapidly Degraded Cytoskeletal Protein
por: Yao, June, et al.
Publicado: (2004)

Intoxication of Host Cells by the T3SS Phospholipase ExoU: PI(4,5)P(2)-Associated, Cytoskeletal Collapse and Late Phase Membrane Blebbing
por: Sato, Hiromi, et al.
Publicado: (2014)

Sema3A Antibody BI-X Prevents Cell Permeability and Cytoskeletal Collapse in HRMECs and Increases Tip Cell Density in Mouse Oxygen-Induced Retinopathy
por: Zippel, Nina, et al.
Publicado: (2022)

Cytoskeletal Proteins of Actinobacteria
por: Letek, Michal, et al.
Publicado: (2012)

Cytoskeletal Remodeling in Cancer
por: Aseervatham, Jaya
Publicado: (2020)

Cytoskeletal Tensegrity in Microgravity
por: Gardiner, John
Publicado: (2021)

Collective Dynamics of Active Cytoskeletal Networks
por: Köhler, Simone, et al.
Publicado: (2011)

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody
por: Luo, Wenjie, et al.
Publicado: (2015)

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation
por: Alquezar, Carolina, et al.
Publicado: (2021)

An Integrated Cytoskeletal Model of Neurite Outgrowth
por: Miller, Kyle E., et al.
Publicado: (2018)

Simulating Society Transitions: Standstill, Collapse and Growth in an Evolving Network Model
por: Xu, Guanghua, et al.
Publicado: (2013)

Identifying pathways to metal–organic framework collapse during solvent activation with molecular simulations
por: Manning, Joseph R. H., et al.
Publicado: (2023)

Simulation of the Decay Ao -> tau+tau- in the ATLAS Inner Detector
por: Luthaus, P, et al.
Publicado: (1995)

Programmed cortical ER collapse drives selective ER degradation and inheritance in yeast meiosis
por: Otto, George Maxwell, et al.
Publicado: (2021)

Cytoskeletal Interactions at the Nuclear Envelope Mediated by Nesprins
por: Taranum, Surayya, et al.
Publicado: (2012)

Aminopeptidases do not directly degrade tau protein
por: Chow, K Martin, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_qn3gompp81i0rk55itja23t18u