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Longitudinal Associations between Adolescent Psychotic Experiences and Depressive Symptoms
BACKGROUND: Psychotic experiences are prevalent in community samples and are highly correlated with depressive symptoms. This study aimed to investigate the longitudinal associations between psychotic experiences and depressive symptoms between adolescence and young adulthood. METHOD: Prospective co...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146535/ https://www.ncbi.nlm.nih.gov/pubmed/25162230 http://dx.doi.org/10.1371/journal.pone.0105758 |
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author | Sullivan, Sarah A. Wiles, Nicola Kounali, Daphne Lewis, Glyn Heron, Jon Cannon, Mary Mahedy, Liam Jones, Peter B. Stochl, Jan Zammit, Stan |
author_facet | Sullivan, Sarah A. Wiles, Nicola Kounali, Daphne Lewis, Glyn Heron, Jon Cannon, Mary Mahedy, Liam Jones, Peter B. Stochl, Jan Zammit, Stan |
author_sort | Sullivan, Sarah A. |
collection | PubMed |
description | BACKGROUND: Psychotic experiences are prevalent in community samples and are highly correlated with depressive symptoms. This study aimed to investigate the longitudinal associations between psychotic experiences and depressive symptoms between adolescence and young adulthood. METHOD: Prospective cohort study with a 6 year follow-up in a community sample of 7632 adolescents and young adults. Depressive symptoms were assessed with the Short Moods and Feelings Questionnaire and psychotic experiences with a semi-structured clinical interview at 12 and 18 years. Longitudinal and cross-sectional associations were investigated with regression and structural equation models. RESULTS: Depressive symptoms and psychotic experiences were associated at each time-point (12 years r = 0.486 [95% CI 0.457, 0.515]; 18 years r = 0.286 [95% CI 0.233, 0.339]) and there were longitudinal within-phenotype associations (depressive symptoms r = 0.252 [95% CI 0.205, 0.299]; psychotic experiences r = 0.662 [95% CI 0.595, 0.729]). There was an across-phenotype association between psychotic experiences at 12 and depressive symptoms at 18 r = 0.139 [95% CI 0.086, 0.192; p<0.001], but no association between depressive symptoms at 12 and psychotic experiences at 18 r = −0.022 [95% CI −0.032, 0.077; p = 0.891]. CONCLUSIONS: Longitudinal across-phenotype associations were substantially weaker than cross-sectional associations or within-phenotype longitudinal associations. Whilst psychotic experiences at 12 years were associated with a small increase in depression at 18 years, depression at 12 years was not associated with psychotic experiences at 18 years once across-phenotype cross-sectional and within-phenotype longitudinal associations were accounted for. This suggests that the biological mechanisms underlying depression at this age do not increase subsequent risk of psychotic experiences once they resolve. |
format | Online Article Text |
id | pubmed-4146535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41465352014-08-29 Longitudinal Associations between Adolescent Psychotic Experiences and Depressive Symptoms Sullivan, Sarah A. Wiles, Nicola Kounali, Daphne Lewis, Glyn Heron, Jon Cannon, Mary Mahedy, Liam Jones, Peter B. Stochl, Jan Zammit, Stan PLoS One Research Article BACKGROUND: Psychotic experiences are prevalent in community samples and are highly correlated with depressive symptoms. This study aimed to investigate the longitudinal associations between psychotic experiences and depressive symptoms between adolescence and young adulthood. METHOD: Prospective cohort study with a 6 year follow-up in a community sample of 7632 adolescents and young adults. Depressive symptoms were assessed with the Short Moods and Feelings Questionnaire and psychotic experiences with a semi-structured clinical interview at 12 and 18 years. Longitudinal and cross-sectional associations were investigated with regression and structural equation models. RESULTS: Depressive symptoms and psychotic experiences were associated at each time-point (12 years r = 0.486 [95% CI 0.457, 0.515]; 18 years r = 0.286 [95% CI 0.233, 0.339]) and there were longitudinal within-phenotype associations (depressive symptoms r = 0.252 [95% CI 0.205, 0.299]; psychotic experiences r = 0.662 [95% CI 0.595, 0.729]). There was an across-phenotype association between psychotic experiences at 12 and depressive symptoms at 18 r = 0.139 [95% CI 0.086, 0.192; p<0.001], but no association between depressive symptoms at 12 and psychotic experiences at 18 r = −0.022 [95% CI −0.032, 0.077; p = 0.891]. CONCLUSIONS: Longitudinal across-phenotype associations were substantially weaker than cross-sectional associations or within-phenotype longitudinal associations. Whilst psychotic experiences at 12 years were associated with a small increase in depression at 18 years, depression at 12 years was not associated with psychotic experiences at 18 years once across-phenotype cross-sectional and within-phenotype longitudinal associations were accounted for. This suggests that the biological mechanisms underlying depression at this age do not increase subsequent risk of psychotic experiences once they resolve. Public Library of Science 2014-08-27 /pmc/articles/PMC4146535/ /pubmed/25162230 http://dx.doi.org/10.1371/journal.pone.0105758 Text en © 2014 Sullivan et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Sullivan, Sarah A. Wiles, Nicola Kounali, Daphne Lewis, Glyn Heron, Jon Cannon, Mary Mahedy, Liam Jones, Peter B. Stochl, Jan Zammit, Stan Longitudinal Associations between Adolescent Psychotic Experiences and Depressive Symptoms |
title | Longitudinal Associations between Adolescent Psychotic Experiences and Depressive Symptoms |
title_full | Longitudinal Associations between Adolescent Psychotic Experiences and Depressive Symptoms |
title_fullStr | Longitudinal Associations between Adolescent Psychotic Experiences and Depressive Symptoms |
title_full_unstemmed | Longitudinal Associations between Adolescent Psychotic Experiences and Depressive Symptoms |
title_short | Longitudinal Associations between Adolescent Psychotic Experiences and Depressive Symptoms |
title_sort | longitudinal associations between adolescent psychotic experiences and depressive symptoms |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146535/ https://www.ncbi.nlm.nih.gov/pubmed/25162230 http://dx.doi.org/10.1371/journal.pone.0105758 |
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