Beyond Genotype: Serotonin Transporter Epigenetic Modification Predicts Human Brain Function

We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem a...

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Autores principales: Nikolova, Yuliya S., Koenen, Karestan C., Galea, Sandro, Wang, Chiou-Miin, Seney, Marianne L., Sibille, Etienne, Williamson, Douglas E., Hariri, Ahmad R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146649/
https://www.ncbi.nlm.nih.gov/pubmed/25086606
http://dx.doi.org/10.1038/nn.3778
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author Nikolova, Yuliya S.
Koenen, Karestan C.
Galea, Sandro
Wang, Chiou-Miin
Seney, Marianne L.
Sibille, Etienne
Williamson, Douglas E.
Hariri, Ahmad R.
author_facet Nikolova, Yuliya S.
Koenen, Karestan C.
Galea, Sandro
Wang, Chiou-Miin
Seney, Marianne L.
Sibille, Etienne
Williamson, Douglas E.
Hariri, Ahmad R.
author_sort Nikolova, Yuliya S.
collection PubMed
description We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem amygdala tissue. These patterns were independent of functional genetic variation in the same region. Furthermore, the association with amygdala reactivity was replicated in a second cohort and was robust to both sampling methods and age.
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spelling pubmed-41466492015-03-01 Beyond Genotype: Serotonin Transporter Epigenetic Modification Predicts Human Brain Function Nikolova, Yuliya S. Koenen, Karestan C. Galea, Sandro Wang, Chiou-Miin Seney, Marianne L. Sibille, Etienne Williamson, Douglas E. Hariri, Ahmad R. Nat Neurosci Article We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem amygdala tissue. These patterns were independent of functional genetic variation in the same region. Furthermore, the association with amygdala reactivity was replicated in a second cohort and was robust to both sampling methods and age. 2014-08-03 2014-09 /pmc/articles/PMC4146649/ /pubmed/25086606 http://dx.doi.org/10.1038/nn.3778 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Nikolova, Yuliya S.
Koenen, Karestan C.
Galea, Sandro
Wang, Chiou-Miin
Seney, Marianne L.
Sibille, Etienne
Williamson, Douglas E.
Hariri, Ahmad R.
Beyond Genotype: Serotonin Transporter Epigenetic Modification Predicts Human Brain Function
title Beyond Genotype: Serotonin Transporter Epigenetic Modification Predicts Human Brain Function
title_full Beyond Genotype: Serotonin Transporter Epigenetic Modification Predicts Human Brain Function
title_fullStr Beyond Genotype: Serotonin Transporter Epigenetic Modification Predicts Human Brain Function
title_full_unstemmed Beyond Genotype: Serotonin Transporter Epigenetic Modification Predicts Human Brain Function
title_short Beyond Genotype: Serotonin Transporter Epigenetic Modification Predicts Human Brain Function
title_sort beyond genotype: serotonin transporter epigenetic modification predicts human brain function
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146649/
https://www.ncbi.nlm.nih.gov/pubmed/25086606
http://dx.doi.org/10.1038/nn.3778
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