Mullinamides A and B, New Cyclopeptides Produced by the Ruth Mullins Coal Mine Fire Isolate Streptomyces sp. RM-27-46

Two new cyclopeptides, mullinamides A [cyclo-(-l-Gly-l-Glu-l-Val-l-Ile-l-Pro-)] and B [cyclo-(-l-Glu-l-Met-l-Pro-)] were isolated from the crude extract of terrestrial Streptomyces sp. RM-27-46 along with the three known cyclopeptides surugamide A [cyclo-(-l-Ile-d-Ile-l-Lys-l-Ile-d-Phe-d-Leu-l-Ile-d...

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Autores principales: Wang, Xiachang, Shaaban, Khaled A., Elshahawi, Sherif I., Ponomareva, Larissa V., Sunkara, Manjula, Copley, Gregory C., Hower, James C., Morris, Andrew J., Kharel, Madan K., Thorson, Jon S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146655/
https://www.ncbi.nlm.nih.gov/pubmed/24713874
http://dx.doi.org/10.1038/ja.2014.37
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author Wang, Xiachang
Shaaban, Khaled A.
Elshahawi, Sherif I.
Ponomareva, Larissa V.
Sunkara, Manjula
Copley, Gregory C.
Hower, James C.
Morris, Andrew J.
Kharel, Madan K.
Thorson, Jon S.
author_facet Wang, Xiachang
Shaaban, Khaled A.
Elshahawi, Sherif I.
Ponomareva, Larissa V.
Sunkara, Manjula
Copley, Gregory C.
Hower, James C.
Morris, Andrew J.
Kharel, Madan K.
Thorson, Jon S.
author_sort Wang, Xiachang
collection PubMed
description Two new cyclopeptides, mullinamides A [cyclo-(-l-Gly-l-Glu-l-Val-l-Ile-l-Pro-)] and B [cyclo-(-l-Glu-l-Met-l-Pro-)] were isolated from the crude extract of terrestrial Streptomyces sp. RM-27-46 along with the three known cyclopeptides surugamide A [cyclo-(-l-Ile-d-Ile-l-Lys-l-Ile-d-Phe-d-Leu-l-Ile-d-Ala-)], cyclo-(-l-Pro-l-Phe-) and cyclo-(-l-Pro-l-Leu-). The structures of the new compounds were elucidated by the cumulative analyses of NMR spectroscopy and high resolution mass spectrometry. While mullinamides A and B displayed no appreciable antimicrobial/fungal activity or cytotoxicity, this study highlights the first reported antibacterial activity of surugamide A.
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spelling pubmed-41466552015-02-01 Mullinamides A and B, New Cyclopeptides Produced by the Ruth Mullins Coal Mine Fire Isolate Streptomyces sp. RM-27-46 Wang, Xiachang Shaaban, Khaled A. Elshahawi, Sherif I. Ponomareva, Larissa V. Sunkara, Manjula Copley, Gregory C. Hower, James C. Morris, Andrew J. Kharel, Madan K. Thorson, Jon S. J Antibiot (Tokyo) Article Two new cyclopeptides, mullinamides A [cyclo-(-l-Gly-l-Glu-l-Val-l-Ile-l-Pro-)] and B [cyclo-(-l-Glu-l-Met-l-Pro-)] were isolated from the crude extract of terrestrial Streptomyces sp. RM-27-46 along with the three known cyclopeptides surugamide A [cyclo-(-l-Ile-d-Ile-l-Lys-l-Ile-d-Phe-d-Leu-l-Ile-d-Ala-)], cyclo-(-l-Pro-l-Phe-) and cyclo-(-l-Pro-l-Leu-). The structures of the new compounds were elucidated by the cumulative analyses of NMR spectroscopy and high resolution mass spectrometry. While mullinamides A and B displayed no appreciable antimicrobial/fungal activity or cytotoxicity, this study highlights the first reported antibacterial activity of surugamide A. 2014-04-09 2014-08 /pmc/articles/PMC4146655/ /pubmed/24713874 http://dx.doi.org/10.1038/ja.2014.37 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Wang, Xiachang
Shaaban, Khaled A.
Elshahawi, Sherif I.
Ponomareva, Larissa V.
Sunkara, Manjula
Copley, Gregory C.
Hower, James C.
Morris, Andrew J.
Kharel, Madan K.
Thorson, Jon S.
Mullinamides A and B, New Cyclopeptides Produced by the Ruth Mullins Coal Mine Fire Isolate Streptomyces sp. RM-27-46
title Mullinamides A and B, New Cyclopeptides Produced by the Ruth Mullins Coal Mine Fire Isolate Streptomyces sp. RM-27-46
title_full Mullinamides A and B, New Cyclopeptides Produced by the Ruth Mullins Coal Mine Fire Isolate Streptomyces sp. RM-27-46
title_fullStr Mullinamides A and B, New Cyclopeptides Produced by the Ruth Mullins Coal Mine Fire Isolate Streptomyces sp. RM-27-46
title_full_unstemmed Mullinamides A and B, New Cyclopeptides Produced by the Ruth Mullins Coal Mine Fire Isolate Streptomyces sp. RM-27-46
title_short Mullinamides A and B, New Cyclopeptides Produced by the Ruth Mullins Coal Mine Fire Isolate Streptomyces sp. RM-27-46
title_sort mullinamides a and b, new cyclopeptides produced by the ruth mullins coal mine fire isolate streptomyces sp. rm-27-46
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146655/
https://www.ncbi.nlm.nih.gov/pubmed/24713874
http://dx.doi.org/10.1038/ja.2014.37
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