Cargando…
Multiple Sclerosis Presents with Psychotic Symptoms and Coexists with Hypertrophic Cardiomyopathy
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. Psychiatric symptoms are not infrequent during MS, yet onset of MS with psychosis is rarely encountered. A 27-year-old Caucasian male was admitted due to numbness in his right arm and difficulty in walking. His clinica...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147190/ https://www.ncbi.nlm.nih.gov/pubmed/25197588 http://dx.doi.org/10.1155/2014/383108 |
_version_ | 1782332394775248896 |
---|---|
author | Özcan, Muhammed Emin İnce, Bahri Karadeli, Hasan Hüseyin Asil, Talip |
author_facet | Özcan, Muhammed Emin İnce, Bahri Karadeli, Hasan Hüseyin Asil, Talip |
author_sort | Özcan, Muhammed Emin |
collection | PubMed |
description | Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. Psychiatric symptoms are not infrequent during MS, yet onset of MS with psychosis is rarely encountered. A 27-year-old Caucasian male was admitted due to numbness in his right arm and difficulty in walking. His clinical and laboratorial exams lead to the MS diagnosis. Nine months earlier, he also developed psychotic disorder, not otherwise specified (PD-NOS). His sudden onset of PD-NOS, his rapid and complete response to antipsychotics, and a relatively short interval between psychiatric and neurological signs indicate a high likelihood that PD-NOS was a manifestation of underlying MS. He also suffers from hypertrophic obstructive cardiomyopathy (HOCM). The patient's neurological complaints were recovered with methylprednisolone (1 g/day, i.v.) given for five days. Glatiramer acetate (1 × 1 tb.s.c.) was prescribed for consolidation and, after nine months of his admission, the patient fully recovered from neurological and psychiatric complaints. Interestingly, very recent studies indicate specific alpha-actinin antibodies in MS and alpha-actinin mutations cause HOCM. Thus, concurrence of MS with HOCM can be even a new syndrome, if further genetic studies prove. |
format | Online Article Text |
id | pubmed-4147190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41471902014-09-07 Multiple Sclerosis Presents with Psychotic Symptoms and Coexists with Hypertrophic Cardiomyopathy Özcan, Muhammed Emin İnce, Bahri Karadeli, Hasan Hüseyin Asil, Talip Case Rep Neurol Med Case Report Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. Psychiatric symptoms are not infrequent during MS, yet onset of MS with psychosis is rarely encountered. A 27-year-old Caucasian male was admitted due to numbness in his right arm and difficulty in walking. His clinical and laboratorial exams lead to the MS diagnosis. Nine months earlier, he also developed psychotic disorder, not otherwise specified (PD-NOS). His sudden onset of PD-NOS, his rapid and complete response to antipsychotics, and a relatively short interval between psychiatric and neurological signs indicate a high likelihood that PD-NOS was a manifestation of underlying MS. He also suffers from hypertrophic obstructive cardiomyopathy (HOCM). The patient's neurological complaints were recovered with methylprednisolone (1 g/day, i.v.) given for five days. Glatiramer acetate (1 × 1 tb.s.c.) was prescribed for consolidation and, after nine months of his admission, the patient fully recovered from neurological and psychiatric complaints. Interestingly, very recent studies indicate specific alpha-actinin antibodies in MS and alpha-actinin mutations cause HOCM. Thus, concurrence of MS with HOCM can be even a new syndrome, if further genetic studies prove. Hindawi Publishing Corporation 2014 2014-08-13 /pmc/articles/PMC4147190/ /pubmed/25197588 http://dx.doi.org/10.1155/2014/383108 Text en Copyright © 2014 Muhammed Emin Özcan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Özcan, Muhammed Emin İnce, Bahri Karadeli, Hasan Hüseyin Asil, Talip Multiple Sclerosis Presents with Psychotic Symptoms and Coexists with Hypertrophic Cardiomyopathy |
title | Multiple Sclerosis Presents with Psychotic Symptoms and Coexists with Hypertrophic Cardiomyopathy |
title_full | Multiple Sclerosis Presents with Psychotic Symptoms and Coexists with Hypertrophic Cardiomyopathy |
title_fullStr | Multiple Sclerosis Presents with Psychotic Symptoms and Coexists with Hypertrophic Cardiomyopathy |
title_full_unstemmed | Multiple Sclerosis Presents with Psychotic Symptoms and Coexists with Hypertrophic Cardiomyopathy |
title_short | Multiple Sclerosis Presents with Psychotic Symptoms and Coexists with Hypertrophic Cardiomyopathy |
title_sort | multiple sclerosis presents with psychotic symptoms and coexists with hypertrophic cardiomyopathy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147190/ https://www.ncbi.nlm.nih.gov/pubmed/25197588 http://dx.doi.org/10.1155/2014/383108 |
work_keys_str_mv | AT ozcanmuhammedemin multiplesclerosispresentswithpsychoticsymptomsandcoexistswithhypertrophiccardiomyopathy AT incebahri multiplesclerosispresentswithpsychoticsymptomsandcoexistswithhypertrophiccardiomyopathy AT karadelihasanhuseyin multiplesclerosispresentswithpsychoticsymptomsandcoexistswithhypertrophiccardiomyopathy AT asiltalip multiplesclerosispresentswithpsychoticsymptomsandcoexistswithhypertrophiccardiomyopathy |