Abnormality in Wnt Signaling is Causatively Associated with Oxidative Stress-Induced Intestinal Tumorigenesis in MUTYH-Null Mice

MUTYH is a DNA glycosylase that excises adenine paired with 8-oxoguanine to prevent mutagenesis in mammals. Biallelic germline mutations of MUTYH have been found in patients predisposed to a recessive form of familial adenomatous polyposis (MAP: MUTYH-associated polyposis). We previously reported th...

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Detalles Bibliográficos
Autores principales: Isoda, Takuro, Nakatsu, Yoshimichi, Yamauchi, Kazumi, Piao, Jingshu, Yao, Takashi, Honda, Hiroshi, Nakabeppu, Yusaku, Tsuzuki, Teruhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147226/
https://www.ncbi.nlm.nih.gov/pubmed/25170306
http://dx.doi.org/10.7150/ijbs.9241

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