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SCF(FBXW7α) modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stability

The intra-S-checkpoint is essential to control cell progression through S phase under normal conditions and in response to replication stress. When DNA lesions are detected, replication fork progression is blocked allowing time for repair to avoid genomic instability and the risk of cancer. DNA repl...

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Detalles Bibliográficos
Autores principales:	Giráldez, Servando, Herrero-Ruiz, Joaquín, Mora-Santos, Mar, Japón, Miguel Á., Tortolero, Maria, Romero, Francisco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147330/ https://www.ncbi.nlm.nih.gov/pubmed/24970797

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