Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding

The GLI genes, GLI1 and GLI2, are transcription factors that regulate target genes at the distal end of the canonical Hedgehog (HH) signaling pathway (SHH->PTCH->SMO->GLI), tightly regulated in embryonic development, tissue patterning and differentiation. Both GLI1 and GLI2 are oncogenes, c...

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Detalles Bibliográficos
Autores principales: Agyeman, Akwasi, Jha, Babal K, Mazumdar, Tapati, Houghton, Janet A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147340/
https://www.ncbi.nlm.nih.gov/pubmed/24962990

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