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DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment

The increased production of reactive oxygen species (ROS) plays a key role in pathogenesis of diabetic complications. ROS are generated by exogenous and endogenous factors such as during hyperglycemia. When ROS production exceeds the detoxification and scavenging capacity of the cell, oxidative stre...

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Autores principales: Moreli, Jusciele Brogin, Santos, Janine Hertzog, Rocha, Clarissa Ribeiro, Damasceno, Débora Cristina, Morceli, Glilciane, Rudge, Marilza Vieira, Bevilacqua, Estela, Calderon, Iracema Mattos Paranhos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147359/
https://www.ncbi.nlm.nih.gov/pubmed/25197655
http://dx.doi.org/10.1155/2014/676758
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author Moreli, Jusciele Brogin
Santos, Janine Hertzog
Rocha, Clarissa Ribeiro
Damasceno, Débora Cristina
Morceli, Glilciane
Rudge, Marilza Vieira
Bevilacqua, Estela
Calderon, Iracema Mattos Paranhos
author_facet Moreli, Jusciele Brogin
Santos, Janine Hertzog
Rocha, Clarissa Ribeiro
Damasceno, Débora Cristina
Morceli, Glilciane
Rudge, Marilza Vieira
Bevilacqua, Estela
Calderon, Iracema Mattos Paranhos
author_sort Moreli, Jusciele Brogin
collection PubMed
description The increased production of reactive oxygen species (ROS) plays a key role in pathogenesis of diabetic complications. ROS are generated by exogenous and endogenous factors such as during hyperglycemia. When ROS production exceeds the detoxification and scavenging capacity of the cell, oxidative stress ensues. Oxidative stress induces DNA damage and when DNA damage exceeds the cellular capacity to repair it, the accumulation of errors can overwhelm the cell resulting in cell death or fixation of genome mutations that can be transmitted to future cell generations. These mutations can lead to and/or play a role in cancer development. This review aims at (i) understanding the types and consequences of DNA damage during hyperglycemic pregnancy; (ii) identifying the biological role of DNA repair during pregnancy, and (iii) proposing clinical interventions to maintain genome integrity. While hyperglycemia can damage the maternal genetic material, the impact of hyperglycemia on fetal cells is still unclear. DNA repair mechanisms may be important to prevent the deleterious effects of hyperglycemia both in mother and in fetus DNA and, as such, prevent the development of diseases in adulthood. Hence, in clinical practice, maternal glycemic control may represent an important point of intervention to prevent the deleterious effects of maternal hyperglycemia to DNA.
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spelling pubmed-41473592014-09-07 DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment Moreli, Jusciele Brogin Santos, Janine Hertzog Rocha, Clarissa Ribeiro Damasceno, Débora Cristina Morceli, Glilciane Rudge, Marilza Vieira Bevilacqua, Estela Calderon, Iracema Mattos Paranhos Biomed Res Int Review Article The increased production of reactive oxygen species (ROS) plays a key role in pathogenesis of diabetic complications. ROS are generated by exogenous and endogenous factors such as during hyperglycemia. When ROS production exceeds the detoxification and scavenging capacity of the cell, oxidative stress ensues. Oxidative stress induces DNA damage and when DNA damage exceeds the cellular capacity to repair it, the accumulation of errors can overwhelm the cell resulting in cell death or fixation of genome mutations that can be transmitted to future cell generations. These mutations can lead to and/or play a role in cancer development. This review aims at (i) understanding the types and consequences of DNA damage during hyperglycemic pregnancy; (ii) identifying the biological role of DNA repair during pregnancy, and (iii) proposing clinical interventions to maintain genome integrity. While hyperglycemia can damage the maternal genetic material, the impact of hyperglycemia on fetal cells is still unclear. DNA repair mechanisms may be important to prevent the deleterious effects of hyperglycemia both in mother and in fetus DNA and, as such, prevent the development of diseases in adulthood. Hence, in clinical practice, maternal glycemic control may represent an important point of intervention to prevent the deleterious effects of maternal hyperglycemia to DNA. Hindawi Publishing Corporation 2014 2014-08-14 /pmc/articles/PMC4147359/ /pubmed/25197655 http://dx.doi.org/10.1155/2014/676758 Text en Copyright © 2014 Jusciele Brogin Moreli et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Moreli, Jusciele Brogin
Santos, Janine Hertzog
Rocha, Clarissa Ribeiro
Damasceno, Débora Cristina
Morceli, Glilciane
Rudge, Marilza Vieira
Bevilacqua, Estela
Calderon, Iracema Mattos Paranhos
DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment
title DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment
title_full DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment
title_fullStr DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment
title_full_unstemmed DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment
title_short DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment
title_sort dna damage and its cellular response in mother and fetus exposed to hyperglycemic environment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147359/
https://www.ncbi.nlm.nih.gov/pubmed/25197655
http://dx.doi.org/10.1155/2014/676758
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