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Epidemiologic study of myelodysplastic syndromes in a multiethnic, inner city cohort

Little is known about the epidemiology of MDS in minority populations. The IPSS and newly released IPSS-R are important clinical tools in prognostication of patients with MDS. Therefore, we conducted a retrospective epidemiological analysis of MDS in an ethnically diverse cohort of patients. Demogra...

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Autores principales: Sridharan, Ashwin, Jain, Rishi, Bachhuber, Marcus A, Yu, Yiting, Ramesh, KH, Gundabolu, Krishna, Friedman, Ellen W, Verma, Amit K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147386/
https://www.ncbi.nlm.nih.gov/pubmed/25170429
http://dx.doi.org/10.1186/2162-3619-3-22
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author Sridharan, Ashwin
Jain, Rishi
Bachhuber, Marcus A
Yu, Yiting
Ramesh, KH
Gundabolu, Krishna
Friedman, Ellen W
Verma, Amit K
author_facet Sridharan, Ashwin
Jain, Rishi
Bachhuber, Marcus A
Yu, Yiting
Ramesh, KH
Gundabolu, Krishna
Friedman, Ellen W
Verma, Amit K
author_sort Sridharan, Ashwin
collection PubMed
description Little is known about the epidemiology of MDS in minority populations. The IPSS and newly released IPSS-R are important clinical tools in prognostication of patients with MDS. Therefore, we conducted a retrospective epidemiological analysis of MDS in an ethnically diverse cohort of patients. Demographics, disease characteristics, and survival were determined in 161 patients seen at Montefiore Medical Center from 1997 to 2011. We observed that Hispanics presented at a younger age than blacks and whites (68 vs. 73.7 vs. 75.6 years); this difference was significant (p = 0.01). A trend towards greater prevalence of thrombocytopenia in Hispanics was observed, but this was not significant (p = 0.08). No other differences between the groups were observed. Overall median survival after diagnosis was the highest among Hispanics (8.6 years) followed by blacks (6.2 years) and Caucasians (3.7). Adjusted hazard ratios however did not show significant differences in risk of death between the groups. The IPSS-R showed slightly better discrimination when compared to the IPSS in this cohort (Somers Dxy 0.39 vs. 0.35, respectively) but observed survival more was more closely approximated by IPSS than by IPSS-R. Our study highlights the possibility of ethnic differences in the presentation of MDS and raises questions regarding which prognostic system is more predictive in this population.
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spelling pubmed-41473862014-08-29 Epidemiologic study of myelodysplastic syndromes in a multiethnic, inner city cohort Sridharan, Ashwin Jain, Rishi Bachhuber, Marcus A Yu, Yiting Ramesh, KH Gundabolu, Krishna Friedman, Ellen W Verma, Amit K Exp Hematol Oncol Research Little is known about the epidemiology of MDS in minority populations. The IPSS and newly released IPSS-R are important clinical tools in prognostication of patients with MDS. Therefore, we conducted a retrospective epidemiological analysis of MDS in an ethnically diverse cohort of patients. Demographics, disease characteristics, and survival were determined in 161 patients seen at Montefiore Medical Center from 1997 to 2011. We observed that Hispanics presented at a younger age than blacks and whites (68 vs. 73.7 vs. 75.6 years); this difference was significant (p = 0.01). A trend towards greater prevalence of thrombocytopenia in Hispanics was observed, but this was not significant (p = 0.08). No other differences between the groups were observed. Overall median survival after diagnosis was the highest among Hispanics (8.6 years) followed by blacks (6.2 years) and Caucasians (3.7). Adjusted hazard ratios however did not show significant differences in risk of death between the groups. The IPSS-R showed slightly better discrimination when compared to the IPSS in this cohort (Somers Dxy 0.39 vs. 0.35, respectively) but observed survival more was more closely approximated by IPSS than by IPSS-R. Our study highlights the possibility of ethnic differences in the presentation of MDS and raises questions regarding which prognostic system is more predictive in this population. BioMed Central 2014-08-23 /pmc/articles/PMC4147386/ /pubmed/25170429 http://dx.doi.org/10.1186/2162-3619-3-22 Text en Copyright © 2014 Sridharan et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Sridharan, Ashwin
Jain, Rishi
Bachhuber, Marcus A
Yu, Yiting
Ramesh, KH
Gundabolu, Krishna
Friedman, Ellen W
Verma, Amit K
Epidemiologic study of myelodysplastic syndromes in a multiethnic, inner city cohort
title Epidemiologic study of myelodysplastic syndromes in a multiethnic, inner city cohort
title_full Epidemiologic study of myelodysplastic syndromes in a multiethnic, inner city cohort
title_fullStr Epidemiologic study of myelodysplastic syndromes in a multiethnic, inner city cohort
title_full_unstemmed Epidemiologic study of myelodysplastic syndromes in a multiethnic, inner city cohort
title_short Epidemiologic study of myelodysplastic syndromes in a multiethnic, inner city cohort
title_sort epidemiologic study of myelodysplastic syndromes in a multiethnic, inner city cohort
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147386/
https://www.ncbi.nlm.nih.gov/pubmed/25170429
http://dx.doi.org/10.1186/2162-3619-3-22
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