Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers

BACKGROUND: Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue. MATERIALS AND METHOD: A total of 34 patients were analysed...

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Detalles Bibliográficos
Autores principales: Honnegowda, Thittamaranahalli Muguregowda, Kumar, Pramod, Udupa, Padmanabha, Rao, Pragna, Bhandary, Siddhartha, Mahato, Krishna Kumar, Sharan, Anurag, Mayya, Shreemathi S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147456/
https://www.ncbi.nlm.nih.gov/pubmed/25190917
http://dx.doi.org/10.4103/0970-0358.138952
Descripción
Sumario:BACKGROUND: Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue. MATERIALS AND METHOD: A total of 34 patients were analysed from two groups: Limited access dressing (LAD) group (n = 17) and conventional dressing group (n = 17). RESULTS: Patients treated with LAD that exerts combination of intermittent negative pressure and moist wound-healing had shown a significant increase in the hydroxyproline (P = 0.026), total protein (P = 0.004), GPx level (P = 0.030) and GST level (P = 0.045). CONCLUSION: Patients treated with LAD indicated significantly better anabolic effect on wound-healing compared to that of patients treated with conventional dressing.

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