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Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers

BACKGROUND: Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue. MATERIALS AND METHOD: A total of 34 patients were analysed...

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Autores principales: Honnegowda, Thittamaranahalli Muguregowda, Kumar, Pramod, Udupa, Padmanabha, Rao, Pragna, Bhandary, Siddhartha, Mahato, Krishna Kumar, Sharan, Anurag, Mayya, Shreemathi S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147456/
https://www.ncbi.nlm.nih.gov/pubmed/25190917
http://dx.doi.org/10.4103/0970-0358.138952
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author Honnegowda, Thittamaranahalli Muguregowda
Kumar, Pramod
Udupa, Padmanabha
Rao, Pragna
Bhandary, Siddhartha
Mahato, Krishna Kumar
Sharan, Anurag
Mayya, Shreemathi S.
author_facet Honnegowda, Thittamaranahalli Muguregowda
Kumar, Pramod
Udupa, Padmanabha
Rao, Pragna
Bhandary, Siddhartha
Mahato, Krishna Kumar
Sharan, Anurag
Mayya, Shreemathi S.
author_sort Honnegowda, Thittamaranahalli Muguregowda
collection PubMed
description BACKGROUND: Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue. MATERIALS AND METHOD: A total of 34 patients were analysed from two groups: Limited access dressing (LAD) group (n = 17) and conventional dressing group (n = 17). RESULTS: Patients treated with LAD that exerts combination of intermittent negative pressure and moist wound-healing had shown a significant increase in the hydroxyproline (P = 0.026), total protein (P = 0.004), GPx level (P = 0.030) and GST level (P = 0.045). CONCLUSION: Patients treated with LAD indicated significantly better anabolic effect on wound-healing compared to that of patients treated with conventional dressing.
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spelling pubmed-41474562014-09-04 Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers Honnegowda, Thittamaranahalli Muguregowda Kumar, Pramod Udupa, Padmanabha Rao, Pragna Bhandary, Siddhartha Mahato, Krishna Kumar Sharan, Anurag Mayya, Shreemathi S. Indian J Plast Surg Original Article BACKGROUND: Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue. MATERIALS AND METHOD: A total of 34 patients were analysed from two groups: Limited access dressing (LAD) group (n = 17) and conventional dressing group (n = 17). RESULTS: Patients treated with LAD that exerts combination of intermittent negative pressure and moist wound-healing had shown a significant increase in the hydroxyproline (P = 0.026), total protein (P = 0.004), GPx level (P = 0.030) and GST level (P = 0.045). CONCLUSION: Patients treated with LAD indicated significantly better anabolic effect on wound-healing compared to that of patients treated with conventional dressing. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4147456/ /pubmed/25190917 http://dx.doi.org/10.4103/0970-0358.138952 Text en Copyright: © Indian Journal of Plastic Surgery http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Honnegowda, Thittamaranahalli Muguregowda
Kumar, Pramod
Udupa, Padmanabha
Rao, Pragna
Bhandary, Siddhartha
Mahato, Krishna Kumar
Sharan, Anurag
Mayya, Shreemathi S.
Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers
title Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers
title_full Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers
title_fullStr Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers
title_full_unstemmed Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers
title_short Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers
title_sort effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147456/
https://www.ncbi.nlm.nih.gov/pubmed/25190917
http://dx.doi.org/10.4103/0970-0358.138952
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