OA02.07. Experimental evaluation of “yakritashula vinashini vatika” w.s.r. to hepatoprotective potential in albino rats.

PURPOSE: According to the latest W.H.O. data published in April, 2011 death due to liver disease in India has reached 2.3% of total deaths. This stands 27th in the world. Till date, there is no effective medicine for treating hepatic disorders in modern medicine, so efforts have been made to search for effective Hepatoprotective drug. The purpose of the present study was to evaluate the Hepatoprotective activity of Yakritashula Vinashini Vatika (YSV) against Carbon tetrachloride induced Hepatotoxicity in rats. METHOD: The toxicant CCl4 was used to induce Hepatotoxicity at a dose of (1 ml/kg b. w.) as 1:1 mixture with olive oil. YSV was administered in the dose of (200 and 400 mg/kg b .w. /day) orally for 28 days. And the results were compared with known standard drug Silymarin (100mg/kg b. w.). The Hepatoprotective effect of YSV was evaluated by the assessment of biochemical parameters such as SGOT, SGPT ALP, Total Billirubin, Serum Protein, Lipid profile. RESULT: The toxic effect of CCl4 was controlled in the animals treated with the YSV by way of restoration of level of liver function biochemistry similar to that of the standard drug Silymarin. Among the YSV treated groups significant Hepatoprotective activity was observed. In the histopathological studies, the liver sections of rats treated with YSV 200 & 400 mg/kg respectively, a normal hepatic architecture was seen with only moderate accumulation of fatty lobules and mild degree of cell necrosis, clearly indicating the protection offered by drug. CONCLUSION: From the results it can be concluded that YSV possesses Hepatoprotective effect against CCl4 induced liver damage in rats.