PA02.03. Pharmaceutical standardization of Ropya raj rasa

PURPOSE: New drug discovery is the need of the hour as we see considerable increase in the number and nature of diseases. Though Ayurveda, the ancient science of medicine, has number of unique formulations in its armory. These formulations in the Rasashastra texts which are said to be possessing very high therapeutic values but are not manufactured by any pharmaceutical industries due to lack of SOP and SMP regarding the pharmaceutical procedures. Ropya Raj Rasa is one such formulation which has ambiguity regarding its ingredients, pharmaceutical procedure and the final product. At the same time it has been mentioned highly effective in Bhagandara. Hence with an objective to find out answers to this ambiguity regarding pharmaceutical procedure of Ropya Raj Rasa. METHOD: The present study was conducted where in all available meanings for “Rasendra ” and “Mlechhakshara” were considered and used for preparation. Totally six different combinations were formulated for “Rasendra” and “Mlechhakshara” meaning. At the end of the study, the optimum temperature required for the formulation, the accurate combination of “Rasendra” and “Mlechhakshara”, the drugs to be taken in the name of “Rasendra” and “Mlechhakshara” were concluded as a part of pharmaceutical standardization. RESULT: Out of six combinations, one with the Hingula and Navasadara demonstrated the signs of completion as mentioned in the text “Bhramati Taravata on Dhamana”. CONCLUSION: Samples containing Somala did not demonstrate the sign of completion. Thus it would be rational to conclude that with the reference Rasendra is Hingula and Mlechhakshara is Navasadara.