PA02.05. Pharmaceutical and analytical evaluation of Lasuna Kshirpaka w.s.r to charaka and sharangadhara methods.

PURPOSE: Ksheerpaka i.e. milk used in the medicated form is the unique feature of Ayurveda. Now a day, for Ksheerpaka preparation, method stated by Sharangadhara is generally followed. Charaka has mentioned Lasuna Ksheerpaka which is prepared by different proportions than that of Sharangadhara. Though ingredients used for preparation by each method are same, variation in proportion of ingredients may alter their respective efficacies. The present study aims at pharmaceutical and analytical evaluation of Lasuna Ksheerpaka prepared by two different proportions viz. Charaka samhita (sample C) and Sharangadhara Samhita (sample S) and to hypothesize probable biotransformation during Lasuna Ksheerpaka preparation. METHOD: The samples were prepared according to the reference in Charaka Samhita(Chi. 5/94) and Sharangadhara Samhita (Madhyama. 1/161). The samples were evaluated by the tests like Methylene Blue Reduction (MBR), Solid non fat (SNF), specific gravity, pH, Gas Chromatography etc. RESULT: The results obtained from these tests indicated rapid transformations and degradation of active volatile compounds found in Garlic. The quantitative analysis of Lasuna Ksheerpaka samples done by Gas Chromatography study showed higher retention of Allin with its less destruction to further volatile Sulphur compounds in sample C (0.410 mg/gm) in comparison with sample S (0.211 mg/gm). CONCLUSION: The preservation of Allin to restore the medicinal properties of Garlic is the main aim of modern Pharmaceutics. The same purpose of Allin preservation and retention of medicinal properties of Garlic can be achieved by Lasuna kshirapaka prepared according to Charaka Samhita in comparison with Lasuna kshirapaka prepared according to Sharangadhara Samhita. Thus, Lasuna kshirapaka preparation according to reference of Charaka Samhita seems to be a better option within the scope of this study.