PA02.09. Role of surface electron microscopy (SEMEDAX) in analysis of agasti patra bhavit shuddha manashilla

PURPOSE: SEMEDAX is a highly sophisticated analytical technique for elemental analysis of any inorganic material. It can help us to evaluate the changes which take place in inorganic material after shodhan, which can scientifically relates the thing or can help us to generate the evidence which will help to rule out the reason of various types of shodhan specifically mention in Granthas. METHOD: Shodhan of Manashilla was performed as described in Rasatarangani (11/113). SEMEDAX was done of both the sample of Ashuddha and Shuddha Manashilla. In SEMEDAX Coating of sample were done and then placed under scanning electron microscope. RESULT: SEMEDAX reveilles the presence of all elements present in Manashilla along with its atomic percentage value. There is a change in atomic percentages of all the elements after shodhan which indicate that shodhan bring changes at its atomic level which may be responsible for its biological properties. CONCLUSION: Oxygen, Sulfur, copper, calcium, Arsenic, Thorium was the detected elements present in Manashilla. After shodhan there is alteration in its atomic percentage value SEMEDAX revealed that percentage of arsenic decreases after shodhan whereas percentage of oxygen and calcium rose. from this we can conclude that shodhan not only remove external impurities but it bring changes to its atomic level which is responsible for its pharmacological action and may be responsible for targeting the drug to the site of action, thus SEMEDAX is a crucial tool to shows that shodhan brings elemental alteration with the help of this tool we can proof that shodhan has scientific approach and its an unavoidable procedure.