PA02.14. A review on immunomodulator activity of Yashtimadhu (Glycyrriza Glabra).

PURPOSE: Recurrent respiratory infection, diarrhoea etc. are the most common causes of morbidity in immune compromised children. Majority of children below the age of 5 years do get 7–8 episodes of cold per year. In developing countries about 15 million children under the age of 5 years die each year. Respiratory infection account for 4 million of deaths. In India 15% of death occurs during infancy and 1–5 years of age are due to respiratory infections. This statistic shows that children are more vulnerable to infection because their immune system is less or under developed. At this age any intervention which could motivate their immune system, may prove boon to them. Ayurveda with its concept of Rasayana is holding various medicinal plants which are excellent immunomodulator and capable to reduce the morbidity status. METHOD: Peer review journals were searched to list all medicinal plants with immunomodulator activities, particularly acting on recurrent respiratory infection and recurrent diarrhoeal episodes. Only full texts in English were accepted for the present study. RESULT: Out of all research Yashtimadhu (Glycyrrhiza glabra) was found potent to reduce morbidity rate. It is very cost effective, easily available with highest immunomodulator properties. CONCLUSION: Review suggests there are studies which confirms immunomodulatory effect of Yashtimadhu but recommend further extensive study.