The Coronavirus Nucleocapsid Is a Multifunctional Protein

The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. Recent studies have confirmed that N is a multif...

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Detalles Bibliográficos
Autores principales: McBride, Ruth, van Zyl, Marjorie, Fielding, Burtram C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147684/
https://www.ncbi.nlm.nih.gov/pubmed/25105276
http://dx.doi.org/10.3390/v6082991
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author McBride, Ruth
van Zyl, Marjorie
Fielding, Burtram C.
author_facet McBride, Ruth
van Zyl, Marjorie
Fielding, Burtram C.
author_sort McBride, Ruth
collection PubMed
description The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. Recent studies have confirmed that N is a multifunctional protein. The aim of this review is to highlight the properties and functions of the N protein, with specific reference to (i) the topology; (ii) the intracellular localization and (iii) the functions of the protein.
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spelling pubmed-41476842014-08-28 The Coronavirus Nucleocapsid Is a Multifunctional Protein McBride, Ruth van Zyl, Marjorie Fielding, Burtram C. Viruses Review The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. Recent studies have confirmed that N is a multifunctional protein. The aim of this review is to highlight the properties and functions of the N protein, with specific reference to (i) the topology; (ii) the intracellular localization and (iii) the functions of the protein. MDPI 2014-08-07 /pmc/articles/PMC4147684/ /pubmed/25105276 http://dx.doi.org/10.3390/v6082991 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
McBride, Ruth
van Zyl, Marjorie
Fielding, Burtram C.
The Coronavirus Nucleocapsid Is a Multifunctional Protein
title The Coronavirus Nucleocapsid Is a Multifunctional Protein
title_full The Coronavirus Nucleocapsid Is a Multifunctional Protein
title_fullStr The Coronavirus Nucleocapsid Is a Multifunctional Protein
title_full_unstemmed The Coronavirus Nucleocapsid Is a Multifunctional Protein
title_short The Coronavirus Nucleocapsid Is a Multifunctional Protein
title_sort coronavirus nucleocapsid is a multifunctional protein
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147684/
https://www.ncbi.nlm.nih.gov/pubmed/25105276
http://dx.doi.org/10.3390/v6082991
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