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Application of a Bioinformatics-Based Approach to Identify Novel Putative in vivo BACE1 Substrates
BACE1, a membrane-bound aspartyl protease that is implicated in Alzheimer’s disease, is the first protease to cut the amyloid precursor protein resulting in the generation of amyloid-β and its aggregation to form senile plaques, a hallmark feature of the disease. Few other native BACE1 substrates ha...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Libertas Academica
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147752/ https://www.ncbi.nlm.nih.gov/pubmed/25288897 http://dx.doi.org/10.4137/BECB.S8383 |