Increased Lysosomal Membrane Permeabilization in Oxidant-exposed Macrophages of Human Fibrotic Lungs

A disrupted balance of reduced glutathione (GSH) and iron (Fe) and subsequent enhanced susceptibility of lysosomes of lung macrophages (LMs) to oxidants may play a role in lung fibrogenesis. We assessed cellular Fe/GSH, lysosomal membrane permeabilization (LMP), and cell death in cultures of oxidant...

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Detalles Bibliográficos
Autores principales: Persson, Hans L, Vainikka, Linda K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147753/
https://www.ncbi.nlm.nih.gov/pubmed/25278780
http://dx.doi.org/10.4137/JCD.S13271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147753/
https://www.ncbi.nlm.nih.gov/pubmed/25278780
http://dx.doi.org/10.4137/JCD.S13271

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