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An Empirical Muscle Intracellular Action Potential Model with Multiple Erlang Probability Density Functions based on a Modified Newton Method

The convolution of the transmembrane current of an excitable cell and a weighting function generates a single fiber action potential (SFAP) model by using the volume conductor theory. Here, we propose an empirical muscle IAP model with multiple Erlang probability density functions (PDFs) based on a...

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Detalles Bibliográficos
Autores principales: Kim, Gyutae, Ferdjallah, Mohammed M, McKenzie, Frederic D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147762/
https://www.ncbi.nlm.nih.gov/pubmed/25288900
http://dx.doi.org/10.4137/BECB.S11646
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author Kim, Gyutae
Ferdjallah, Mohammed M
McKenzie, Frederic D
author_facet Kim, Gyutae
Ferdjallah, Mohammed M
McKenzie, Frederic D
author_sort Kim, Gyutae
collection PubMed
description The convolution of the transmembrane current of an excitable cell and a weighting function generates a single fiber action potential (SFAP) model by using the volume conductor theory. Here, we propose an empirical muscle IAP model with multiple Erlang probability density functions (PDFs) based on a modified Newton method. In addition, we generate SFAPs based on our IAP model and referent sources, and use the peak-to-peak ratios (PPRs) of SFAPs for model verification. Through this verification, we find that the relation between an IAP profile and the PPR of its SFAP is consistent with some previous studies, and our IAP model shows close profiles to the referent sources. Moreover, we simulate and discuss some possible ionic activities by using the Erlang PDFs in our IAP model, which might present the underlying activities of ions or their channels during an IAP.
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spelling pubmed-41477622014-10-06 An Empirical Muscle Intracellular Action Potential Model with Multiple Erlang Probability Density Functions based on a Modified Newton Method Kim, Gyutae Ferdjallah, Mohammed M McKenzie, Frederic D Biomed Eng Comput Biol Original Research The convolution of the transmembrane current of an excitable cell and a weighting function generates a single fiber action potential (SFAP) model by using the volume conductor theory. Here, we propose an empirical muscle IAP model with multiple Erlang probability density functions (PDFs) based on a modified Newton method. In addition, we generate SFAPs based on our IAP model and referent sources, and use the peak-to-peak ratios (PPRs) of SFAPs for model verification. Through this verification, we find that the relation between an IAP profile and the PPR of its SFAP is consistent with some previous studies, and our IAP model shows close profiles to the referent sources. Moreover, we simulate and discuss some possible ionic activities by using the Erlang PDFs in our IAP model, which might present the underlying activities of ions or their channels during an IAP. Libertas Academica 2013-04-14 /pmc/articles/PMC4147762/ /pubmed/25288900 http://dx.doi.org/10.4137/BECB.S11646 Text en © 2013 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article published under the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Original Research
Kim, Gyutae
Ferdjallah, Mohammed M
McKenzie, Frederic D
An Empirical Muscle Intracellular Action Potential Model with Multiple Erlang Probability Density Functions based on a Modified Newton Method
title An Empirical Muscle Intracellular Action Potential Model with Multiple Erlang Probability Density Functions based on a Modified Newton Method
title_full An Empirical Muscle Intracellular Action Potential Model with Multiple Erlang Probability Density Functions based on a Modified Newton Method
title_fullStr An Empirical Muscle Intracellular Action Potential Model with Multiple Erlang Probability Density Functions based on a Modified Newton Method
title_full_unstemmed An Empirical Muscle Intracellular Action Potential Model with Multiple Erlang Probability Density Functions based on a Modified Newton Method
title_short An Empirical Muscle Intracellular Action Potential Model with Multiple Erlang Probability Density Functions based on a Modified Newton Method
title_sort empirical muscle intracellular action potential model with multiple erlang probability density functions based on a modified newton method
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147762/
https://www.ncbi.nlm.nih.gov/pubmed/25288900
http://dx.doi.org/10.4137/BECB.S11646
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