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Vitamin D Signaling in Myogenesis: Potential for Treatment of Sarcopenia
Muscle mass and strength progressively decrease with age, which results in a condition known as sarcopenia. Sarcopenia would lead to physical disability, poor quality of life, and death. Therefore, much is expected of an effective intervention for sarcopenia. Epidemiologic, clinical, and laboratory...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147791/ https://www.ncbi.nlm.nih.gov/pubmed/25197630 http://dx.doi.org/10.1155/2014/121254 |
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author | Wagatsuma, Akira Sakuma, Kunihiro |
author_facet | Wagatsuma, Akira Sakuma, Kunihiro |
author_sort | Wagatsuma, Akira |
collection | PubMed |
description | Muscle mass and strength progressively decrease with age, which results in a condition known as sarcopenia. Sarcopenia would lead to physical disability, poor quality of life, and death. Therefore, much is expected of an effective intervention for sarcopenia. Epidemiologic, clinical, and laboratory evidence suggest an effect of vitamin D on muscle function. However, the precise molecular and cellular mechanisms remain to be elucidated. Recent studies suggest that vitamin D receptor (VDR) might be expressed in muscle fibers and vitamin D signaling via VDR plays a role in the regulation of myoblast proliferation and differentiation. Understanding how vitamin D signaling contributes to myogenesis will provide a valuable insight into an effective nutritional strategy to moderate sarcopenia. Here we will summarize the current knowledge about the effect of vitamin D on skeletal muscle and myogenic cells and discuss the potential for treatment of sarcopenia. |
format | Online Article Text |
id | pubmed-4147791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41477912014-09-07 Vitamin D Signaling in Myogenesis: Potential for Treatment of Sarcopenia Wagatsuma, Akira Sakuma, Kunihiro Biomed Res Int Review Article Muscle mass and strength progressively decrease with age, which results in a condition known as sarcopenia. Sarcopenia would lead to physical disability, poor quality of life, and death. Therefore, much is expected of an effective intervention for sarcopenia. Epidemiologic, clinical, and laboratory evidence suggest an effect of vitamin D on muscle function. However, the precise molecular and cellular mechanisms remain to be elucidated. Recent studies suggest that vitamin D receptor (VDR) might be expressed in muscle fibers and vitamin D signaling via VDR plays a role in the regulation of myoblast proliferation and differentiation. Understanding how vitamin D signaling contributes to myogenesis will provide a valuable insight into an effective nutritional strategy to moderate sarcopenia. Here we will summarize the current knowledge about the effect of vitamin D on skeletal muscle and myogenic cells and discuss the potential for treatment of sarcopenia. Hindawi Publishing Corporation 2014 2014-06-30 /pmc/articles/PMC4147791/ /pubmed/25197630 http://dx.doi.org/10.1155/2014/121254 Text en Copyright © 2014 A. Wagatsuma and K. Sakuma. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wagatsuma, Akira Sakuma, Kunihiro Vitamin D Signaling in Myogenesis: Potential for Treatment of Sarcopenia |
title | Vitamin D Signaling in Myogenesis: Potential for Treatment of Sarcopenia |
title_full | Vitamin D Signaling in Myogenesis: Potential for Treatment of Sarcopenia |
title_fullStr | Vitamin D Signaling in Myogenesis: Potential for Treatment of Sarcopenia |
title_full_unstemmed | Vitamin D Signaling in Myogenesis: Potential for Treatment of Sarcopenia |
title_short | Vitamin D Signaling in Myogenesis: Potential for Treatment of Sarcopenia |
title_sort | vitamin d signaling in myogenesis: potential for treatment of sarcopenia |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147791/ https://www.ncbi.nlm.nih.gov/pubmed/25197630 http://dx.doi.org/10.1155/2014/121254 |
work_keys_str_mv | AT wagatsumaakira vitamindsignalinginmyogenesispotentialfortreatmentofsarcopenia AT sakumakunihiro vitamindsignalinginmyogenesispotentialfortreatmentofsarcopenia |