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Vitamin D Signaling in Myogenesis: Potential for Treatment of Sarcopenia

Muscle mass and strength progressively decrease with age, which results in a condition known as sarcopenia. Sarcopenia would lead to physical disability, poor quality of life, and death. Therefore, much is expected of an effective intervention for sarcopenia. Epidemiologic, clinical, and laboratory...

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Detalles Bibliográficos
Autores principales: Wagatsuma, Akira, Sakuma, Kunihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147791/
https://www.ncbi.nlm.nih.gov/pubmed/25197630
http://dx.doi.org/10.1155/2014/121254
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author Wagatsuma, Akira
Sakuma, Kunihiro
author_facet Wagatsuma, Akira
Sakuma, Kunihiro
author_sort Wagatsuma, Akira
collection PubMed
description Muscle mass and strength progressively decrease with age, which results in a condition known as sarcopenia. Sarcopenia would lead to physical disability, poor quality of life, and death. Therefore, much is expected of an effective intervention for sarcopenia. Epidemiologic, clinical, and laboratory evidence suggest an effect of vitamin D on muscle function. However, the precise molecular and cellular mechanisms remain to be elucidated. Recent studies suggest that vitamin D receptor (VDR) might be expressed in muscle fibers and vitamin D signaling via VDR plays a role in the regulation of myoblast proliferation and differentiation. Understanding how vitamin D signaling contributes to myogenesis will provide a valuable insight into an effective nutritional strategy to moderate sarcopenia. Here we will summarize the current knowledge about the effect of vitamin D on skeletal muscle and myogenic cells and discuss the potential for treatment of sarcopenia.
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spelling pubmed-41477912014-09-07 Vitamin D Signaling in Myogenesis: Potential for Treatment of Sarcopenia Wagatsuma, Akira Sakuma, Kunihiro Biomed Res Int Review Article Muscle mass and strength progressively decrease with age, which results in a condition known as sarcopenia. Sarcopenia would lead to physical disability, poor quality of life, and death. Therefore, much is expected of an effective intervention for sarcopenia. Epidemiologic, clinical, and laboratory evidence suggest an effect of vitamin D on muscle function. However, the precise molecular and cellular mechanisms remain to be elucidated. Recent studies suggest that vitamin D receptor (VDR) might be expressed in muscle fibers and vitamin D signaling via VDR plays a role in the regulation of myoblast proliferation and differentiation. Understanding how vitamin D signaling contributes to myogenesis will provide a valuable insight into an effective nutritional strategy to moderate sarcopenia. Here we will summarize the current knowledge about the effect of vitamin D on skeletal muscle and myogenic cells and discuss the potential for treatment of sarcopenia. Hindawi Publishing Corporation 2014 2014-06-30 /pmc/articles/PMC4147791/ /pubmed/25197630 http://dx.doi.org/10.1155/2014/121254 Text en Copyright © 2014 A. Wagatsuma and K. Sakuma. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wagatsuma, Akira
Sakuma, Kunihiro
Vitamin D Signaling in Myogenesis: Potential for Treatment of Sarcopenia
title Vitamin D Signaling in Myogenesis: Potential for Treatment of Sarcopenia
title_full Vitamin D Signaling in Myogenesis: Potential for Treatment of Sarcopenia
title_fullStr Vitamin D Signaling in Myogenesis: Potential for Treatment of Sarcopenia
title_full_unstemmed Vitamin D Signaling in Myogenesis: Potential for Treatment of Sarcopenia
title_short Vitamin D Signaling in Myogenesis: Potential for Treatment of Sarcopenia
title_sort vitamin d signaling in myogenesis: potential for treatment of sarcopenia
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147791/
https://www.ncbi.nlm.nih.gov/pubmed/25197630
http://dx.doi.org/10.1155/2014/121254
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