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Comparative evaluation of serum antioxidant levels in periodontally diseased patients: An interventional study

BACKGROUND: Periodontal disease is an immune-inflammatory disease characterized by connective tissue breakdown, loss of attachment and alveolar bone resorption. In normal physiology, there is a dynamic equilibrium between reactive oxygen species activity and antioxidant defense capacity and when tha...

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Autores principales: Thomas, Biju, Madani, Shabeer Mohamed, Prasad, B. Rajendra, Kumari, Suchetha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147810/
https://www.ncbi.nlm.nih.gov/pubmed/25191070
http://dx.doi.org/10.4103/0976-237X.137938
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author Thomas, Biju
Madani, Shabeer Mohamed
Prasad, B. Rajendra
Kumari, Suchetha
author_facet Thomas, Biju
Madani, Shabeer Mohamed
Prasad, B. Rajendra
Kumari, Suchetha
author_sort Thomas, Biju
collection PubMed
description BACKGROUND: Periodontal disease is an immune-inflammatory disease characterized by connective tissue breakdown, loss of attachment and alveolar bone resorption. In normal physiology, there is a dynamic equilibrium between reactive oxygen species activity and antioxidant defense capacity and when that equilibrium shifts in favor of reactive oxygen species, oxidative stress results. Oxidative stress is thought to play a causative role in the pathogenesis of periodontal diseases. Catalase (CAT) protects cells from hydrogen peroxide generated within them. Even though, CAT is not essential for some cell types under normal conditions, it plays an important role countering the effects of oxidative stress on the cell. AIM: This study was designed to estimate and compare the CAT and total antioxidant capacity (TAOC) levels in the serum of periodontitis, gingivitis, and healthy individuals before and after nonsurgical periodontal therapy. MATERIALS AND METHODS: This study was conducted in the Department of Periodontics, A. B. Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangalore. The study was designed as a single blinded interventional study comprising of 75 subjects, inclusive of both sexes and divided into three groups of 25 patients each. Patients were categorized into chronic periodontitis, gingivitis and healthy. The severity of inflammation was assessed by using gingival index and pocket probing depth. Biochemical analysis was done to estimate the TAOC and CAT levels before and after nonsurgical periodontal therapy. Results obtained were then statistically analyzed using ANOVA test and paired t-test. RESULTS: The results showed a higher level of serum TAOC and CAT in the healthy group compared with the other groups. The difference was found to be statistically significant (P < 0.0001). The posttreatment levels of TAOC were statistically higher than the pretreatment levels in periodontitis group.
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spelling pubmed-41478102014-09-04 Comparative evaluation of serum antioxidant levels in periodontally diseased patients: An interventional study Thomas, Biju Madani, Shabeer Mohamed Prasad, B. Rajendra Kumari, Suchetha Contemp Clin Dent Original Article BACKGROUND: Periodontal disease is an immune-inflammatory disease characterized by connective tissue breakdown, loss of attachment and alveolar bone resorption. In normal physiology, there is a dynamic equilibrium between reactive oxygen species activity and antioxidant defense capacity and when that equilibrium shifts in favor of reactive oxygen species, oxidative stress results. Oxidative stress is thought to play a causative role in the pathogenesis of periodontal diseases. Catalase (CAT) protects cells from hydrogen peroxide generated within them. Even though, CAT is not essential for some cell types under normal conditions, it plays an important role countering the effects of oxidative stress on the cell. AIM: This study was designed to estimate and compare the CAT and total antioxidant capacity (TAOC) levels in the serum of periodontitis, gingivitis, and healthy individuals before and after nonsurgical periodontal therapy. MATERIALS AND METHODS: This study was conducted in the Department of Periodontics, A. B. Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangalore. The study was designed as a single blinded interventional study comprising of 75 subjects, inclusive of both sexes and divided into three groups of 25 patients each. Patients were categorized into chronic periodontitis, gingivitis and healthy. The severity of inflammation was assessed by using gingival index and pocket probing depth. Biochemical analysis was done to estimate the TAOC and CAT levels before and after nonsurgical periodontal therapy. Results obtained were then statistically analyzed using ANOVA test and paired t-test. RESULTS: The results showed a higher level of serum TAOC and CAT in the healthy group compared with the other groups. The difference was found to be statistically significant (P < 0.0001). The posttreatment levels of TAOC were statistically higher than the pretreatment levels in periodontitis group. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4147810/ /pubmed/25191070 http://dx.doi.org/10.4103/0976-237X.137938 Text en Copyright: © Contemporary Clinical Dentistry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Thomas, Biju
Madani, Shabeer Mohamed
Prasad, B. Rajendra
Kumari, Suchetha
Comparative evaluation of serum antioxidant levels in periodontally diseased patients: An interventional study
title Comparative evaluation of serum antioxidant levels in periodontally diseased patients: An interventional study
title_full Comparative evaluation of serum antioxidant levels in periodontally diseased patients: An interventional study
title_fullStr Comparative evaluation of serum antioxidant levels in periodontally diseased patients: An interventional study
title_full_unstemmed Comparative evaluation of serum antioxidant levels in periodontally diseased patients: An interventional study
title_short Comparative evaluation of serum antioxidant levels in periodontally diseased patients: An interventional study
title_sort comparative evaluation of serum antioxidant levels in periodontally diseased patients: an interventional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147810/
https://www.ncbi.nlm.nih.gov/pubmed/25191070
http://dx.doi.org/10.4103/0976-237X.137938
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