Genome-Wide Mutant Fitness Profiling Identifies Nutritional Requirements for Optimal Growth of Yersinia pestis in Deep Tissue

Rapid growth in deep tissue is essential to the high virulence of Yersinia pestis, causative agent of plague. To better understand the mechanisms underlying this unusual ability, we used transposon mutagenesis and high-throughput sequencing (Tn-seq) to systematically probe the Y. pestis genome for e...

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Detalles Bibliográficos
Autores principales: Palace, Samantha G., Proulx, Megan K., Lu, Shan, Baker, Richard E., Goguen, Jon D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147864/
https://www.ncbi.nlm.nih.gov/pubmed/25139902
http://dx.doi.org/10.1128/mBio.01385-14

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