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Dendritic cells: key players in human herpesvirus 8 infection and pathogenesis
Human herpesvirus 8 (HHV-8; Kaposi’s sarcoma-associated herpesvirus) is an oncogenic gammaherpesvirus that primarily infects cells of the immune and vascular systems. HHV-8 interacts with and targets professional antigen presenting cells and influences their function. Infection alters the maturation...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148009/ https://www.ncbi.nlm.nih.gov/pubmed/25221546 http://dx.doi.org/10.3389/fmicb.2014.00452 |
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author | Campbell, Diana M. Rappocciolo, Giovanna Jenkins, Frank J. Rinaldo, Charles R. |
author_facet | Campbell, Diana M. Rappocciolo, Giovanna Jenkins, Frank J. Rinaldo, Charles R. |
author_sort | Campbell, Diana M. |
collection | PubMed |
description | Human herpesvirus 8 (HHV-8; Kaposi’s sarcoma-associated herpesvirus) is an oncogenic gammaherpesvirus that primarily infects cells of the immune and vascular systems. HHV-8 interacts with and targets professional antigen presenting cells and influences their function. Infection alters the maturation, antigen presentation, and immune activation capabilities of certain dendritic cells (DC) despite non-robust lytic replication in these cells. DC sustains a low level of antiviral functionality during HHV-8 infection in vitro. This may explain the ability of healthy individuals to effectively control this virus without disease. Following an immune compromising event, such as organ transplantation or human immunodeficiency virus type 1 infection, a reduced cellular antiviral response against HHV-8 compounded with skewed DC cytokine production and antigen presentation likely contributes to the development of HHV-8 associated diseases, i.e., Kaposi’s sarcoma and certain B cell lymphomas. In this review we focus on the role of DC in the establishment of HHV-8 primary and latent infection, the functional state of DC during HHV-8 infection, and the current understanding of the factors influencing virus-DC interactions in the context of HHV-8-associated disease. |
format | Online Article Text |
id | pubmed-4148009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41480092014-09-12 Dendritic cells: key players in human herpesvirus 8 infection and pathogenesis Campbell, Diana M. Rappocciolo, Giovanna Jenkins, Frank J. Rinaldo, Charles R. Front Microbiol Microbiology Human herpesvirus 8 (HHV-8; Kaposi’s sarcoma-associated herpesvirus) is an oncogenic gammaherpesvirus that primarily infects cells of the immune and vascular systems. HHV-8 interacts with and targets professional antigen presenting cells and influences their function. Infection alters the maturation, antigen presentation, and immune activation capabilities of certain dendritic cells (DC) despite non-robust lytic replication in these cells. DC sustains a low level of antiviral functionality during HHV-8 infection in vitro. This may explain the ability of healthy individuals to effectively control this virus without disease. Following an immune compromising event, such as organ transplantation or human immunodeficiency virus type 1 infection, a reduced cellular antiviral response against HHV-8 compounded with skewed DC cytokine production and antigen presentation likely contributes to the development of HHV-8 associated diseases, i.e., Kaposi’s sarcoma and certain B cell lymphomas. In this review we focus on the role of DC in the establishment of HHV-8 primary and latent infection, the functional state of DC during HHV-8 infection, and the current understanding of the factors influencing virus-DC interactions in the context of HHV-8-associated disease. Frontiers Media S.A. 2014-08-28 /pmc/articles/PMC4148009/ /pubmed/25221546 http://dx.doi.org/10.3389/fmicb.2014.00452 Text en Copyright © 2014 Campbell, Rappocciolo, Jenkins and Rinaldo. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Campbell, Diana M. Rappocciolo, Giovanna Jenkins, Frank J. Rinaldo, Charles R. Dendritic cells: key players in human herpesvirus 8 infection and pathogenesis |
title | Dendritic cells: key players in human herpesvirus 8 infection and pathogenesis |
title_full | Dendritic cells: key players in human herpesvirus 8 infection and pathogenesis |
title_fullStr | Dendritic cells: key players in human herpesvirus 8 infection and pathogenesis |
title_full_unstemmed | Dendritic cells: key players in human herpesvirus 8 infection and pathogenesis |
title_short | Dendritic cells: key players in human herpesvirus 8 infection and pathogenesis |
title_sort | dendritic cells: key players in human herpesvirus 8 infection and pathogenesis |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148009/ https://www.ncbi.nlm.nih.gov/pubmed/25221546 http://dx.doi.org/10.3389/fmicb.2014.00452 |
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