Cargando…

Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population

BACKGROUND: Fatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, hypertension, and atherosclerosis. However, little is known a...

Descripción completa

Detalles Bibliográficos
Autores principales: Fuseya, Takahiro, Furuhashi, Masato, Yuda, Satoshi, Muranaka, Atsuko, Kawamukai, Mina, Mita, Tomohiro, Ishimura, Shutaro, Watanabe, Yuki, Hoshina, Kyoko, Tanaka, Marenao, Ohno, Kohei, Akasaka, Hiroshi, Ohnishi, Hirofumi, Yoshida, Hideaki, Saitoh, Shigeyuki, Shimamoto, Kazuaki, Miura, Tetsuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148010/
https://www.ncbi.nlm.nih.gov/pubmed/25142635
http://dx.doi.org/10.1186/s12933-014-0126-7
_version_ 1782332546667773952
author Fuseya, Takahiro
Furuhashi, Masato
Yuda, Satoshi
Muranaka, Atsuko
Kawamukai, Mina
Mita, Tomohiro
Ishimura, Shutaro
Watanabe, Yuki
Hoshina, Kyoko
Tanaka, Marenao
Ohno, Kohei
Akasaka, Hiroshi
Ohnishi, Hirofumi
Yoshida, Hideaki
Saitoh, Shigeyuki
Shimamoto, Kazuaki
Miura, Tetsuji
author_facet Fuseya, Takahiro
Furuhashi, Masato
Yuda, Satoshi
Muranaka, Atsuko
Kawamukai, Mina
Mita, Tomohiro
Ishimura, Shutaro
Watanabe, Yuki
Hoshina, Kyoko
Tanaka, Marenao
Ohno, Kohei
Akasaka, Hiroshi
Ohnishi, Hirofumi
Yoshida, Hideaki
Saitoh, Shigeyuki
Shimamoto, Kazuaki
Miura, Tetsuji
author_sort Fuseya, Takahiro
collection PubMed
description BACKGROUND: Fatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, hypertension, and atherosclerosis. However, little is known about role of FABP4 in cardiac function. METHODS: From the database of the Tanno-Sobetsu Study, data for 190 subjects (male/female: 82/108) who were not treated with any medication and underwent echocardiography in 2011 or 2012 were retrieved for analyses of relationships between serum FABP4 concentration, metabolic markers and parameters of echocardiography. RESULTS: Serum FABP4 level was positively correlated with age, body mass index (BMI), blood pressure (BP), LDL cholesterol, HOMA-R and mean left ventricular (LV) wall thickness (LVWT, males: r = 0.315, females: r = 0.401, p < 0.01) and was negatively correlated with HDL cholesterol, estimated glomerular filtration rate (eGFR) and peak myocardial velocity during early diastole (e’; males: r = −0.434, females: r = −0.353, p < 0.01), an index of LV diastolic function. However, no significant correlation was found between FABP4 level and LV end-diastolic dimension, LV ejection fraction or LV mass index. There were significant correlations of e’ with age, BMI, BP, eGFR, brain natriuretic peptide (BNP), FABP4, metabolic markers and LVWT. Multivariate regression analysis adjusted by HOMA-R, BMI, eGFR, BNP or LVWT in addition to age, gender and BP revealed that serum FABP4 concentration was independently correlated with e’. CONCLUSIONS: Elevation of circulating FABP4 may contribute to LV diastolic dysfunction in a general population.
format Online
Article
Text
id pubmed-4148010
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-41480102014-08-29 Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population Fuseya, Takahiro Furuhashi, Masato Yuda, Satoshi Muranaka, Atsuko Kawamukai, Mina Mita, Tomohiro Ishimura, Shutaro Watanabe, Yuki Hoshina, Kyoko Tanaka, Marenao Ohno, Kohei Akasaka, Hiroshi Ohnishi, Hirofumi Yoshida, Hideaki Saitoh, Shigeyuki Shimamoto, Kazuaki Miura, Tetsuji Cardiovasc Diabetol Original Investigation BACKGROUND: Fatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, hypertension, and atherosclerosis. However, little is known about role of FABP4 in cardiac function. METHODS: From the database of the Tanno-Sobetsu Study, data for 190 subjects (male/female: 82/108) who were not treated with any medication and underwent echocardiography in 2011 or 2012 were retrieved for analyses of relationships between serum FABP4 concentration, metabolic markers and parameters of echocardiography. RESULTS: Serum FABP4 level was positively correlated with age, body mass index (BMI), blood pressure (BP), LDL cholesterol, HOMA-R and mean left ventricular (LV) wall thickness (LVWT, males: r = 0.315, females: r = 0.401, p < 0.01) and was negatively correlated with HDL cholesterol, estimated glomerular filtration rate (eGFR) and peak myocardial velocity during early diastole (e’; males: r = −0.434, females: r = −0.353, p < 0.01), an index of LV diastolic function. However, no significant correlation was found between FABP4 level and LV end-diastolic dimension, LV ejection fraction or LV mass index. There were significant correlations of e’ with age, BMI, BP, eGFR, brain natriuretic peptide (BNP), FABP4, metabolic markers and LVWT. Multivariate regression analysis adjusted by HOMA-R, BMI, eGFR, BNP or LVWT in addition to age, gender and BP revealed that serum FABP4 concentration was independently correlated with e’. CONCLUSIONS: Elevation of circulating FABP4 may contribute to LV diastolic dysfunction in a general population. BioMed Central 2014-08-21 /pmc/articles/PMC4148010/ /pubmed/25142635 http://dx.doi.org/10.1186/s12933-014-0126-7 Text en © Fuseya et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Investigation
Fuseya, Takahiro
Furuhashi, Masato
Yuda, Satoshi
Muranaka, Atsuko
Kawamukai, Mina
Mita, Tomohiro
Ishimura, Shutaro
Watanabe, Yuki
Hoshina, Kyoko
Tanaka, Marenao
Ohno, Kohei
Akasaka, Hiroshi
Ohnishi, Hirofumi
Yoshida, Hideaki
Saitoh, Shigeyuki
Shimamoto, Kazuaki
Miura, Tetsuji
Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population
title Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population
title_full Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population
title_fullStr Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population
title_full_unstemmed Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population
title_short Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population
title_sort elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148010/
https://www.ncbi.nlm.nih.gov/pubmed/25142635
http://dx.doi.org/10.1186/s12933-014-0126-7
work_keys_str_mv AT fuseyatakahiro elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation
AT furuhashimasato elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation
AT yudasatoshi elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation
AT muranakaatsuko elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation
AT kawamukaimina elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation
AT mitatomohiro elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation
AT ishimurashutaro elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation
AT watanabeyuki elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation
AT hoshinakyoko elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation
AT tanakamarenao elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation
AT ohnokohei elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation
AT akasakahiroshi elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation
AT ohnishihirofumi elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation
AT yoshidahideaki elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation
AT saitohshigeyuki elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation
AT shimamotokazuaki elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation
AT miuratetsuji elevationofcirculatingfattyacidbindingprotein4isindependentlyassociatedwithleftventriculardiastolicdysfunctioninageneralpopulation