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Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population
BACKGROUND: Fatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, hypertension, and atherosclerosis. However, little is known a...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148010/ https://www.ncbi.nlm.nih.gov/pubmed/25142635 http://dx.doi.org/10.1186/s12933-014-0126-7 |
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author | Fuseya, Takahiro Furuhashi, Masato Yuda, Satoshi Muranaka, Atsuko Kawamukai, Mina Mita, Tomohiro Ishimura, Shutaro Watanabe, Yuki Hoshina, Kyoko Tanaka, Marenao Ohno, Kohei Akasaka, Hiroshi Ohnishi, Hirofumi Yoshida, Hideaki Saitoh, Shigeyuki Shimamoto, Kazuaki Miura, Tetsuji |
author_facet | Fuseya, Takahiro Furuhashi, Masato Yuda, Satoshi Muranaka, Atsuko Kawamukai, Mina Mita, Tomohiro Ishimura, Shutaro Watanabe, Yuki Hoshina, Kyoko Tanaka, Marenao Ohno, Kohei Akasaka, Hiroshi Ohnishi, Hirofumi Yoshida, Hideaki Saitoh, Shigeyuki Shimamoto, Kazuaki Miura, Tetsuji |
author_sort | Fuseya, Takahiro |
collection | PubMed |
description | BACKGROUND: Fatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, hypertension, and atherosclerosis. However, little is known about role of FABP4 in cardiac function. METHODS: From the database of the Tanno-Sobetsu Study, data for 190 subjects (male/female: 82/108) who were not treated with any medication and underwent echocardiography in 2011 or 2012 were retrieved for analyses of relationships between serum FABP4 concentration, metabolic markers and parameters of echocardiography. RESULTS: Serum FABP4 level was positively correlated with age, body mass index (BMI), blood pressure (BP), LDL cholesterol, HOMA-R and mean left ventricular (LV) wall thickness (LVWT, males: r = 0.315, females: r = 0.401, p < 0.01) and was negatively correlated with HDL cholesterol, estimated glomerular filtration rate (eGFR) and peak myocardial velocity during early diastole (e’; males: r = −0.434, females: r = −0.353, p < 0.01), an index of LV diastolic function. However, no significant correlation was found between FABP4 level and LV end-diastolic dimension, LV ejection fraction or LV mass index. There were significant correlations of e’ with age, BMI, BP, eGFR, brain natriuretic peptide (BNP), FABP4, metabolic markers and LVWT. Multivariate regression analysis adjusted by HOMA-R, BMI, eGFR, BNP or LVWT in addition to age, gender and BP revealed that serum FABP4 concentration was independently correlated with e’. CONCLUSIONS: Elevation of circulating FABP4 may contribute to LV diastolic dysfunction in a general population. |
format | Online Article Text |
id | pubmed-4148010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41480102014-08-29 Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population Fuseya, Takahiro Furuhashi, Masato Yuda, Satoshi Muranaka, Atsuko Kawamukai, Mina Mita, Tomohiro Ishimura, Shutaro Watanabe, Yuki Hoshina, Kyoko Tanaka, Marenao Ohno, Kohei Akasaka, Hiroshi Ohnishi, Hirofumi Yoshida, Hideaki Saitoh, Shigeyuki Shimamoto, Kazuaki Miura, Tetsuji Cardiovasc Diabetol Original Investigation BACKGROUND: Fatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, hypertension, and atherosclerosis. However, little is known about role of FABP4 in cardiac function. METHODS: From the database of the Tanno-Sobetsu Study, data for 190 subjects (male/female: 82/108) who were not treated with any medication and underwent echocardiography in 2011 or 2012 were retrieved for analyses of relationships between serum FABP4 concentration, metabolic markers and parameters of echocardiography. RESULTS: Serum FABP4 level was positively correlated with age, body mass index (BMI), blood pressure (BP), LDL cholesterol, HOMA-R and mean left ventricular (LV) wall thickness (LVWT, males: r = 0.315, females: r = 0.401, p < 0.01) and was negatively correlated with HDL cholesterol, estimated glomerular filtration rate (eGFR) and peak myocardial velocity during early diastole (e’; males: r = −0.434, females: r = −0.353, p < 0.01), an index of LV diastolic function. However, no significant correlation was found between FABP4 level and LV end-diastolic dimension, LV ejection fraction or LV mass index. There were significant correlations of e’ with age, BMI, BP, eGFR, brain natriuretic peptide (BNP), FABP4, metabolic markers and LVWT. Multivariate regression analysis adjusted by HOMA-R, BMI, eGFR, BNP or LVWT in addition to age, gender and BP revealed that serum FABP4 concentration was independently correlated with e’. CONCLUSIONS: Elevation of circulating FABP4 may contribute to LV diastolic dysfunction in a general population. BioMed Central 2014-08-21 /pmc/articles/PMC4148010/ /pubmed/25142635 http://dx.doi.org/10.1186/s12933-014-0126-7 Text en © Fuseya et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Original Investigation Fuseya, Takahiro Furuhashi, Masato Yuda, Satoshi Muranaka, Atsuko Kawamukai, Mina Mita, Tomohiro Ishimura, Shutaro Watanabe, Yuki Hoshina, Kyoko Tanaka, Marenao Ohno, Kohei Akasaka, Hiroshi Ohnishi, Hirofumi Yoshida, Hideaki Saitoh, Shigeyuki Shimamoto, Kazuaki Miura, Tetsuji Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population |
title | Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population |
title_full | Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population |
title_fullStr | Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population |
title_full_unstemmed | Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population |
title_short | Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population |
title_sort | elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148010/ https://www.ncbi.nlm.nih.gov/pubmed/25142635 http://dx.doi.org/10.1186/s12933-014-0126-7 |
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