ROCK inhibition as a therapy for spinal muscular atrophy: understanding the repercussions on multiple cellular targets

Spinal muscular atrophy (SMA) is the most common genetic disease causing infant death, due to an extended loss of motoneurons. This neuromuscular disorder results from deletions and/or mutations within the Survival Motor Neuron 1 (SMN1) gene, leading to a pathological decreased expression of functio...

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Detalles Bibliográficos
Autores principales: Coque, Emmanuelle, Raoul, Cédric, Bowerman, Mélissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148024/
https://www.ncbi.nlm.nih.gov/pubmed/25221469
http://dx.doi.org/10.3389/fnins.2014.00271

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