Identification of kit(M541L) somatic mutation in chronic eosinophilic leukemia, not otherwise specified and its implication in low-dose imatinib response

Activating mutations of KIT receptor tyrosine kinase have been reported in different neoplasms. The M541L KIT substitution (KIT(M541L)) has been described to be associated with pediatric mastocytosis, to enhance growth rate of the affected cells and to confer higher sensitivity to imatinib therapy....

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Detalles Bibliográficos
Autores principales: Iurlo, Alessandra, Gianelli, Umberto, Beghini, Alessandro, Spinelli, Orietta, Orofino, Nicola, Lazzaroni, Francesca, Cambiaghi, Stefano, Intermesoli, Tamara, Rambaldi, Alessandro, Cortelezzi, Agostino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Clinical Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148089/
https://www.ncbi.nlm.nih.gov/pubmed/25015329

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