Synergistic induction of apoptosis by combination of BTK and dual mTORC1/2 inhibitors in diffuse large B cell lymphoma

Diffuse large B cell lymphoma is generally treated by chemotherapy and there is an unmet medical need for novel targeted therapies or combination therapies. Using in vitro screening, we have identified the combination of ibrutinib, an inhibitor of the tyrosine kinase BTK, and AZD2014, an mTOR cataly...

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Detalles Bibliográficos
Autores principales: Ezell, Scott A., Mayo, Michele, Bihani, Teeru, Tepsuporn, Suprawee, Wang, Suping, Passino, Melissa, Grosskurth, Shaun E., Collins, Mike, Parmentier, Julie, Reimer, Corinne, Byth, Kate F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148116/
https://www.ncbi.nlm.nih.gov/pubmed/24970801

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