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Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model

The human sulfatase 1 (hSulf-1) gene encodes an endosulfatase that functions to inhibit the heparin-binding growth factor signaling, including the basic fibroblast growth factor (bFGF)-mediated pathway, by desulfating the cell surface heparan sulfate proteoglycans (HSPGs). bFGF could stimulate cell...

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Autores principales: Xu, Gaoya, Ji, Weidan, Su, Yinghan, Xu, Yang, Yan, Yan, Shen, Shuwen, Li, Xiaoya, Sun, Bin, Qian, Haihua, Chen, Lei, Fu, Xiaohui, Wu, Mengchao, Su, Changqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148119/
https://www.ncbi.nlm.nih.gov/pubmed/24970807
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author Xu, Gaoya
Ji, Weidan
Su, Yinghan
Xu, Yang
Yan, Yan
Shen, Shuwen
Li, Xiaoya
Sun, Bin
Qian, Haihua
Chen, Lei
Fu, Xiaohui
Wu, Mengchao
Su, Changqing
author_facet Xu, Gaoya
Ji, Weidan
Su, Yinghan
Xu, Yang
Yan, Yan
Shen, Shuwen
Li, Xiaoya
Sun, Bin
Qian, Haihua
Chen, Lei
Fu, Xiaohui
Wu, Mengchao
Su, Changqing
author_sort Xu, Gaoya
collection PubMed
description The human sulfatase 1 (hSulf-1) gene encodes an endosulfatase that functions to inhibit the heparin-binding growth factor signaling, including the basic fibroblast growth factor (bFGF)-mediated pathway, by desulfating the cell surface heparan sulfate proteoglycans (HSPGs). bFGF could stimulate cell cycle progression and inhibit cell apoptosis, this biological effect can be reversed by hSulf-1. However, molecular mechanisms have not been fully reported. In the current study, by reactivation of hSulf-1 expression and function in the hSulf-1-negative hepatocellular carcinoma (HCC) cell lines and HCC xenograft tumors, we found that hSulf-1 blocked the bFGF effect on the promotion of cell cycle and inhibition of apoptosis. The bFGF-stimulated activation of protein kinase B (AKT) and extracellular signal-regulated kinase (ERK) pathways was suppressed by hSulf-1, which led to a decreased expression of the target genes Cyclin D1 and Survivin, then finally induced cell cycle arrest and apoptosis in HCC cells. Our data suggested that hSulf-1 may be a suitable target for cancer therapy.
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spelling pubmed-41481192014-08-29 Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model Xu, Gaoya Ji, Weidan Su, Yinghan Xu, Yang Yan, Yan Shen, Shuwen Li, Xiaoya Sun, Bin Qian, Haihua Chen, Lei Fu, Xiaohui Wu, Mengchao Su, Changqing Oncotarget Research Paper The human sulfatase 1 (hSulf-1) gene encodes an endosulfatase that functions to inhibit the heparin-binding growth factor signaling, including the basic fibroblast growth factor (bFGF)-mediated pathway, by desulfating the cell surface heparan sulfate proteoglycans (HSPGs). bFGF could stimulate cell cycle progression and inhibit cell apoptosis, this biological effect can be reversed by hSulf-1. However, molecular mechanisms have not been fully reported. In the current study, by reactivation of hSulf-1 expression and function in the hSulf-1-negative hepatocellular carcinoma (HCC) cell lines and HCC xenograft tumors, we found that hSulf-1 blocked the bFGF effect on the promotion of cell cycle and inhibition of apoptosis. The bFGF-stimulated activation of protein kinase B (AKT) and extracellular signal-regulated kinase (ERK) pathways was suppressed by hSulf-1, which led to a decreased expression of the target genes Cyclin D1 and Survivin, then finally induced cell cycle arrest and apoptosis in HCC cells. Our data suggested that hSulf-1 may be a suitable target for cancer therapy. Impact Journals LLC 2014-06-08 /pmc/articles/PMC4148119/ /pubmed/24970807 Text en Copyright: © 2014 Xu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Xu, Gaoya
Ji, Weidan
Su, Yinghan
Xu, Yang
Yan, Yan
Shen, Shuwen
Li, Xiaoya
Sun, Bin
Qian, Haihua
Chen, Lei
Fu, Xiaohui
Wu, Mengchao
Su, Changqing
Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model
title Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model
title_full Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model
title_fullStr Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model
title_full_unstemmed Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model
title_short Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model
title_sort sulfatase 1 (hsulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148119/
https://www.ncbi.nlm.nih.gov/pubmed/24970807
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