ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells

ERBB3 is an emerging target for cancer therapy among the EGFR family. Contrary to resistance against EGFR and ERBB2 targeting, the genetic inhibition of ERBB3 results in anti-tumorigenic in HCT116 colon cancer cells harboring constitutively active KRAS and PIK3CA mutations. Still, the anti-tumorigen...

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Detalles Bibliográficos
Autores principales: Lee, Hyunji, Lee, Hyunjung, Chin, Hyunjung, Kim, Kyoungmi, Lee, Daekee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148128/
https://www.ncbi.nlm.nih.gov/pubmed/24970817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148128/
https://www.ncbi.nlm.nih.gov/pubmed/24970817

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