Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy

[Image: see text] Diabetes is affecting the life of millions of people. A large proportion of diabetic patients suffer from severe complications such as neuropathic pain, and current treatments for these complications have deleterious side effects. Thus, alternate therapeutic strategies are needed....

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Detalles Bibliográficos
Autores principales: Lee, Kin Sing Stephen, Liu, Jun-Yan, Wagner, Karen M., Pakhomova, Svetlana, Dong, Hua, Morisseau, Christophe, Fu, Samuel H., Yang, Jun, Wang, Peng, Ulu, Arzu, Mate, Christina A., Nguyen, Long V., Hwang, Sung Hee, Edin, Matthew L., Mara, Alexandria A., Wulff, Heike, Newcomer, Marcia E., Zeldin, Darryl C., Hammock, Bruce D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148150/
https://www.ncbi.nlm.nih.gov/pubmed/25079952
http://dx.doi.org/10.1021/jm500694p

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