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Exploring the Influence of the Protein Environment on Metal-Binding Pharmacophores

[Image: see text] The binding of a series of metal-binding pharmacophores (MBPs) related to the ligand 1-hydroxypyridine-2-(1H)-thione (1,2-HOPTO) in the active site of human carbonic anhydrase II (hCAII) has been investigated. The presence and/or position of a single methyl substituent drastically...

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Detalles Bibliográficos
Autores principales:	Martin, David P., Blachly, Patrick G., McCammon, J. Andrew, Cohen, Seth M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148168/ https://www.ncbi.nlm.nih.gov/pubmed/25116076 http://dx.doi.org/10.1021/jm500984b

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