4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency

[Image: see text] CYP51 is a P450 enzyme involved in the biosynthesis of the sterol components of eukaryotic cell membranes. CYP51 inhibitors have been developed to treat infections caused by fungi, and more recently the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. To...

Descripción completa

Detalles Bibliográficos
Autores principales: Calvet, Claudia M., Vieira, Debora F., Choi, Jun Yong, Kellar, Danielle, Cameron, Michael D., Siqueira-Neto, Jair Lage, Gut, Jiri, Johnston, Jonathan B., Lin, Li, Khan, Susan, McKerrow, James H., Roush, William R., Podust, Larissa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148169/
https://www.ncbi.nlm.nih.gov/pubmed/25101801
http://dx.doi.org/10.1021/jm500448u

Ejemplares similares

Ejemplares similares