Design, Synthesis, and Structure–Activity Relationship Studies of a Series of [4-(4-Carboxamidobutyl)]-1-arylpiperazines: Insights into Structural Features Contributing to Dopamine D3 versus D2 Receptor Subtype Selectivity

[Image: see text] Antagonist and partial agonist modulators of the dopamine D3 receptor (D3R) have emerged as promising therapeutics for the treatment of substance abuse and neuropsychiatric disorders. However, development of druglike lead compounds with selectivity for the D3 receptor has been chal...

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Detalles Bibliográficos
Autores principales: Ananthan, Subramaniam, Saini, Surendra K., Zhou, Guangyan, Hobrath, Judith V., Padmalayam, Indira, Zhai, Ling, Bostwick, J. Robert, Antonio, Tamara, Reith, Maarten E. A., McDowell, Shea, Cho, Eunie, McAleer, Leah, Taylor, Michelle, Luedtke, Robert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148173/
https://www.ncbi.nlm.nih.gov/pubmed/25126833
http://dx.doi.org/10.1021/jm500801r

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148173/
https://www.ncbi.nlm.nih.gov/pubmed/25126833
http://dx.doi.org/10.1021/jm500801r

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