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Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite evidence that inhibition of mitochondrial respiratory complex I by metformin is the primary cause of its cell-lineage-specific actions and therapeutic effects, the molecul...

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Detalles Bibliográficos
Autores principales:	Bridges, Hannah R., Jones, Andrew J. Y., Pollak, Michael N., Hirst, Judy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148174/ https://www.ncbi.nlm.nih.gov/pubmed/25017630 http://dx.doi.org/10.1042/BJ20140620

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