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Identification of Allelic Imbalance with a Statistical Model for Subtle Genomic Mosaicism
Genetic heterogeneity in a mixed sample of tumor and normal DNA can confound characterization of the tumor genome. Numerous computational methods have been proposed to detect aberrations in DNA samples from tumor and normal tissue mixtures. Most of these require tumor purities to be at least 10–15%....
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148184/ https://www.ncbi.nlm.nih.gov/pubmed/25166618 http://dx.doi.org/10.1371/journal.pcbi.1003765 |