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Endocytosis and early endosome motility in filamentous fungi

Hyphal growth of filamentous fungi requires microtubule-based long-distance motility of early endosomes. Since the discovery of this process in Ustilago maydis, our understanding of its molecular basis and biological function has greatly advanced. Studies in U. maydis and Aspergillus nidulans reveal...

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Detalles Bibliográficos
Autor principal: Steinberg, Gero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Current Biology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148197/
https://www.ncbi.nlm.nih.gov/pubmed/24835422
http://dx.doi.org/10.1016/j.mib.2014.04.001
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author Steinberg, Gero
author_facet Steinberg, Gero
author_sort Steinberg, Gero
collection PubMed
description Hyphal growth of filamentous fungi requires microtubule-based long-distance motility of early endosomes. Since the discovery of this process in Ustilago maydis, our understanding of its molecular basis and biological function has greatly advanced. Studies in U. maydis and Aspergillus nidulans reveal a complex interplay of the motor proteins kinesin-3 and dynein, which co-operate to support bi-directional motion of early endosomes. Genetic screening has shed light on the molecular mechanisms underpinning motor regulation, revealing Hook protein as general motor adapters on early endosomes. Recently, fascinating insight into unexpected roles for endosome motility has emerged. This includes septin filament formation and cellular distribution of the machinery for protein translation.
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spelling pubmed-41481972014-09-01 Endocytosis and early endosome motility in filamentous fungi Steinberg, Gero Curr Opin Microbiol Article Hyphal growth of filamentous fungi requires microtubule-based long-distance motility of early endosomes. Since the discovery of this process in Ustilago maydis, our understanding of its molecular basis and biological function has greatly advanced. Studies in U. maydis and Aspergillus nidulans reveal a complex interplay of the motor proteins kinesin-3 and dynein, which co-operate to support bi-directional motion of early endosomes. Genetic screening has shed light on the molecular mechanisms underpinning motor regulation, revealing Hook protein as general motor adapters on early endosomes. Recently, fascinating insight into unexpected roles for endosome motility has emerged. This includes septin filament formation and cellular distribution of the machinery for protein translation. Current Biology 2014-08 /pmc/articles/PMC4148197/ /pubmed/24835422 http://dx.doi.org/10.1016/j.mib.2014.04.001 Text en © 2014 The Authors https://creativecommons.org/licenses/by/3.0/This work is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/) .
spellingShingle Article
Steinberg, Gero
Endocytosis and early endosome motility in filamentous fungi
title Endocytosis and early endosome motility in filamentous fungi
title_full Endocytosis and early endosome motility in filamentous fungi
title_fullStr Endocytosis and early endosome motility in filamentous fungi
title_full_unstemmed Endocytosis and early endosome motility in filamentous fungi
title_short Endocytosis and early endosome motility in filamentous fungi
title_sort endocytosis and early endosome motility in filamentous fungi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148197/
https://www.ncbi.nlm.nih.gov/pubmed/24835422
http://dx.doi.org/10.1016/j.mib.2014.04.001
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