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Canonical Non-Homologous End Joining in Mitosis Induces Genome Instability and Is Suppressed by M-phase-Specific Phosphorylation of XRCC4

DNA double-strand breaks (DSBs) can be repaired by one of two major pathways—non-homologous end-joining (NHEJ) and homologous recombination (HR)—depending on whether cells are in G1 or S/G2 phase, respectively. However, the mechanisms of DSB repair during M phase remain largely unclear. In this stud...

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Detalles Bibliográficos
Autores principales:	Terasawa, Masahiro, Shinohara, Akira, Shinohara, Miki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148217/ https://www.ncbi.nlm.nih.gov/pubmed/25166505 http://dx.doi.org/10.1371/journal.pgen.1004563

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