FUS is sequestered in nuclear aggregates in ALS patient fibroblasts

Mutations in the RNA-binding protein FUS have been shown to cause the neurodegenerative disease amyotrophic lateral sclerosis (ALS). We investigate whether mutant FUS protein in ALS patient–derived fibroblasts affects normal FUS functions in the nucleus. We investigated fibroblasts from two ALS pati...

Descripción completa

Detalles Bibliográficos
Autores principales: Schwartz, Jacob C., Podell, Elaine R., Han, Steve S. W., Berry, James D., Eggan, Kevin C., Cech, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148247/
https://www.ncbi.nlm.nih.gov/pubmed/25009283
http://dx.doi.org/10.1091/mbc.E14-05-1007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148247/
https://www.ncbi.nlm.nih.gov/pubmed/25009283
http://dx.doi.org/10.1091/mbc.E14-05-1007

Ejemplares similares