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Long-Term Prognosis of Patients with Carbon Monoxide Poisoning: A Nationwide Cohort Study

BACKGROUND: Carbon monoxide poisoning (COP) often produces severe complications and can be fatal. Because this topic has not been well delineated, we investigated long-term prognoses of patients with COP (COP([+])). METHODS: In this retrospective nationwide cohort study, 441 COP([+]) patients and 88...

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Detalles Bibliográficos
Autores principales: Huang, Chien-Cheng, Chung, Min-Hsien, Weng, Shih-Feng, Chien, Chih-Chiang, Lin, Shio-Jean, Lin, Hung-Jung, Guo, How-Ran, Su, Shih-Bin, Hsu, Chien-Chin, Juan, Chi-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148326/
https://www.ncbi.nlm.nih.gov/pubmed/25167083
http://dx.doi.org/10.1371/journal.pone.0105503
Descripción
Sumario:BACKGROUND: Carbon monoxide poisoning (COP) often produces severe complications and can be fatal. Because this topic has not been well delineated, we investigated long-term prognoses of patients with COP (COP([+])). METHODS: In this retrospective nationwide cohort study, 441 COP([+]) patients and 8820 COP([−]) controls (120) from 1999 to 2010 were selected from Taiwan’s National Health Insurance Research Database. RESULTS: Thirty-seven (8.39%) COP([+]) patients and 142 (1.61%) controls died (P<0.0001) during follow-up. Incidence rate ratios (IRR) of death were 5.24 times higher in COP([+]) patients than in controls (P<0.0001). The risk of death was particularly high in the first month after COP (IRR: 308.78; 95% confidence interval [CI]: 40.79–2337.56), 1 to 6 months after (IRR: 18.92; 95% CI: 7.69–46.56), and 6–12 months after (IRR: 4.73; 95% CI: 1.02–21.90). After adjusting for age, gender, and selected comorbidities, the hazard ratio of death for COP([+]) patients was still 4.097 times higher than for controls. Moreover, older age (≥30 years old), male gender, diabetes mellitus, hypertension, and low income were also independent mortality predictors. CONCLUSIONS: COP significantly increases the risk for long-term mortality. Early follow-up and secondary prevention of death are needed for patients with COP.