Cargando…

Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells

Phloroglucinol is a polyphenolic compound that is used to treat and prevent several human diseases, as it exerts beneficial biological activities, including anti-oxidant, anti-inflammatory and anticancer properties. The aim of the present study was to investigate the effects of phloroglucinol on apo...

Descripción completa

Detalles Bibliográficos
Autores principales: KANG, MI-HYE, KIM, IN-HYE, NAM, TAEK-JEO NG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148371/
https://www.ncbi.nlm.nih.gov/pubmed/25070748
http://dx.doi.org/10.3892/or.2014.3355
_version_ 1782332613429559296
author KANG, MI-HYE
KIM, IN-HYE
NAM, TAEK-JEO NG
author_facet KANG, MI-HYE
KIM, IN-HYE
NAM, TAEK-JEO NG
author_sort KANG, MI-HYE
collection PubMed
description Phloroglucinol is a polyphenolic compound that is used to treat and prevent several human diseases, as it exerts beneficial biological activities, including anti-oxidant, anti-inflammatory and anticancer properties. The aim of the present study was to investigate the effects of phloroglucinol on apoptotic signaling pathways in HT-29 colon cancer cells. The results indicated that phloroglucinol suppressed cell viability and induced apoptosis in HT-29 cells in a concentration-dependent manner. Phloroglucinol treatment of HT-29 cells resulted in characteristic apoptosis-related changes: altered Bcl-2 family proteins, cytochrome c release, and activation of caspase-3 and caspase-8. This study also showed that proteins involved in apoptosis were stimulated by treatment with phloroglucinol. These findings demonstrated that phloroglucinol exerts anticancer activity in HT-29 colon cancer cells through induction of apoptosis.
format Online
Article
Text
id pubmed-4148371
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-41483712014-08-29 Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells KANG, MI-HYE KIM, IN-HYE NAM, TAEK-JEO NG Oncol Rep Articles Phloroglucinol is a polyphenolic compound that is used to treat and prevent several human diseases, as it exerts beneficial biological activities, including anti-oxidant, anti-inflammatory and anticancer properties. The aim of the present study was to investigate the effects of phloroglucinol on apoptotic signaling pathways in HT-29 colon cancer cells. The results indicated that phloroglucinol suppressed cell viability and induced apoptosis in HT-29 cells in a concentration-dependent manner. Phloroglucinol treatment of HT-29 cells resulted in characteristic apoptosis-related changes: altered Bcl-2 family proteins, cytochrome c release, and activation of caspase-3 and caspase-8. This study also showed that proteins involved in apoptosis were stimulated by treatment with phloroglucinol. These findings demonstrated that phloroglucinol exerts anticancer activity in HT-29 colon cancer cells through induction of apoptosis. D.A. Spandidos 2014-10 2014-07-23 /pmc/articles/PMC4148371/ /pubmed/25070748 http://dx.doi.org/10.3892/or.2014.3355 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
KANG, MI-HYE
KIM, IN-HYE
NAM, TAEK-JEO NG
Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells
title Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells
title_full Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells
title_fullStr Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells
title_full_unstemmed Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells
title_short Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells
title_sort phloroglucinol induces apoptosis via apoptotic signaling pathways in ht-29 colon cancer cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148371/
https://www.ncbi.nlm.nih.gov/pubmed/25070748
http://dx.doi.org/10.3892/or.2014.3355
work_keys_str_mv AT kangmihye phloroglucinolinducesapoptosisviaapoptoticsignalingpathwaysinht29coloncancercells
AT kiminhye phloroglucinolinducesapoptosisviaapoptoticsignalingpathwaysinht29coloncancercells
AT namtaekjeong phloroglucinolinducesapoptosisviaapoptoticsignalingpathwaysinht29coloncancercells