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Early Mucosal Sensing of SIV Infection by Paneth Cells Induces IL-1β Production and Initiates Gut Epithelial Disruption

HIV causes rapid CD4+ T cell depletion in the gut mucosa, resulting in immune deficiency and defects in the intestinal epithelial barrier. Breakdown in gut barrier integrity is linked to chronic inflammation and disease progression. However, the early effects of HIV on the gut epithelium, prior to t...

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Detalles Bibliográficos
Autores principales:	Hirao, Lauren A., Grishina, Irina, Bourry, Olivier, Hu, William K., Somrit, Monsicha, Sankaran-Walters, Sumathi, Gaulke, Chris A., Fenton, Anne N., Li, Jay A., Crawford, Robert W., Chuang, Frank, Tarara, Ross, Marco, Maria L., Bäumler, Andreas J., Cheng, Holland, Dandekar, Satya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148401/ https://www.ncbi.nlm.nih.gov/pubmed/25166758 http://dx.doi.org/10.1371/journal.ppat.1004311

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