The Intriguing Regulators of Muscle Mass in Sarcopenia and Muscular Dystrophy

Recent advances in our understanding of the biology of muscle have led to new interest in the pharmacological treatment of muscle wasting. Loss of muscle mass and increased intramuscular fibrosis occur in both sarcopenia and muscular dystrophy. Several regulators (mammalian target of rapamycin, seru...

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Detalles Bibliográficos
Autores principales: Sakuma, Kunihiro, Aoi, Wataru, Yamaguchi, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148637/
https://www.ncbi.nlm.nih.gov/pubmed/25221510
http://dx.doi.org/10.3389/fnagi.2014.00230
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author Sakuma, Kunihiro
Aoi, Wataru
Yamaguchi, Akihiko
author_facet Sakuma, Kunihiro
Aoi, Wataru
Yamaguchi, Akihiko
author_sort Sakuma, Kunihiro
collection PubMed
description Recent advances in our understanding of the biology of muscle have led to new interest in the pharmacological treatment of muscle wasting. Loss of muscle mass and increased intramuscular fibrosis occur in both sarcopenia and muscular dystrophy. Several regulators (mammalian target of rapamycin, serum response factor, atrogin-1, myostatin, etc.) seem to modulate protein synthesis and degradation or transcription of muscle-specific genes during both sarcopenia and muscular dystrophy. This review provides an overview of the adaptive changes in several regulators of muscle mass in both sarcopenia and muscular dystrophy.
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spelling pubmed-41486372014-09-12 The Intriguing Regulators of Muscle Mass in Sarcopenia and Muscular Dystrophy Sakuma, Kunihiro Aoi, Wataru Yamaguchi, Akihiko Front Aging Neurosci Neuroscience Recent advances in our understanding of the biology of muscle have led to new interest in the pharmacological treatment of muscle wasting. Loss of muscle mass and increased intramuscular fibrosis occur in both sarcopenia and muscular dystrophy. Several regulators (mammalian target of rapamycin, serum response factor, atrogin-1, myostatin, etc.) seem to modulate protein synthesis and degradation or transcription of muscle-specific genes during both sarcopenia and muscular dystrophy. This review provides an overview of the adaptive changes in several regulators of muscle mass in both sarcopenia and muscular dystrophy. Frontiers Media S.A. 2014-08-29 /pmc/articles/PMC4148637/ /pubmed/25221510 http://dx.doi.org/10.3389/fnagi.2014.00230 Text en Copyright © 2014 Sakuma, Aoi and Yamaguchi. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Sakuma, Kunihiro
Aoi, Wataru
Yamaguchi, Akihiko
The Intriguing Regulators of Muscle Mass in Sarcopenia and Muscular Dystrophy
title The Intriguing Regulators of Muscle Mass in Sarcopenia and Muscular Dystrophy
title_full The Intriguing Regulators of Muscle Mass in Sarcopenia and Muscular Dystrophy
title_fullStr The Intriguing Regulators of Muscle Mass in Sarcopenia and Muscular Dystrophy
title_full_unstemmed The Intriguing Regulators of Muscle Mass in Sarcopenia and Muscular Dystrophy
title_short The Intriguing Regulators of Muscle Mass in Sarcopenia and Muscular Dystrophy
title_sort intriguing regulators of muscle mass in sarcopenia and muscular dystrophy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148637/
https://www.ncbi.nlm.nih.gov/pubmed/25221510
http://dx.doi.org/10.3389/fnagi.2014.00230
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