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The effect of aging on the frequency, phenotype and cytokine production of human blood CD4 + CXCR5 + T follicular helper cells: comparison of aged and young subjects

BACKGROUND: T cell-dependent B-cell responses decline with age, indicating declined cognate helper activity of aged CD4 + T cells for B cells. However, the mechanisms remain unclear. T follicular helper (Tfh) cells, a novel T helper subset, play an essential role in helping B cells differentiation i...

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Detalles Bibliográficos
Autores principales:	Zhou, Maohua, Zou, Ruqiong, Gan, Huiquan, Liang, Zhimei, Li, Fujun, Lin, Ting, Luo, Yanfei, Cai, Xiaoming, He, Fang, Shen, Erxia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148677/ https://www.ncbi.nlm.nih.gov/pubmed/25177353 http://dx.doi.org/10.1186/1742-4933-11-12

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