An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside

With a constellation of stem cell sources available, researchers hope to utilize their potential for cellular repair as a therapeutic target for disease. However, many lab-to-clinic translational considerations must be given in determining their efficacy, variables such as the host response, effects...

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Detalles Bibliográficos
Autores principales: Dailey, Travis, Metcalf, Christopher, Mosley, Yusef I., Sullivan, Robert, Shinozuka, Kazutaka, Tajiri, Naoki, Pabon, Mibel, Acosta, Sandra, Kaneko, Yuji, van Loveren, Harry, Borlongan, Cesar V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148819/
https://www.ncbi.nlm.nih.gov/pubmed/25177494
http://dx.doi.org/10.3390/jcm2040220
Descripción
Sumario:With a constellation of stem cell sources available, researchers hope to utilize their potential for cellular repair as a therapeutic target for disease. However, many lab-to-clinic translational considerations must be given in determining their efficacy, variables such as the host response, effects on native tissue, and potential for generating tumors. This review will discuss the current knowledge of stem cell research in neurological disease, mainly stroke, with a focus on the benefits, limitations, and clinical potential.

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