An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside

With a constellation of stem cell sources available, researchers hope to utilize their potential for cellular repair as a therapeutic target for disease. However, many lab-to-clinic translational considerations must be given in determining their efficacy, variables such as the host response, effects...

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Autores principales: Dailey, Travis, Metcalf, Christopher, Mosley, Yusef I., Sullivan, Robert, Shinozuka, Kazutaka, Tajiri, Naoki, Pabon, Mibel, Acosta, Sandra, Kaneko, Yuji, van Loveren, Harry, Borlongan, Cesar V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148819/
https://www.ncbi.nlm.nih.gov/pubmed/25177494
http://dx.doi.org/10.3390/jcm2040220
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author Dailey, Travis
Metcalf, Christopher
Mosley, Yusef I.
Sullivan, Robert
Shinozuka, Kazutaka
Tajiri, Naoki
Pabon, Mibel
Acosta, Sandra
Kaneko, Yuji
van Loveren, Harry
Borlongan, Cesar V.
author_facet Dailey, Travis
Metcalf, Christopher
Mosley, Yusef I.
Sullivan, Robert
Shinozuka, Kazutaka
Tajiri, Naoki
Pabon, Mibel
Acosta, Sandra
Kaneko, Yuji
van Loveren, Harry
Borlongan, Cesar V.
author_sort Dailey, Travis
collection PubMed
description With a constellation of stem cell sources available, researchers hope to utilize their potential for cellular repair as a therapeutic target for disease. However, many lab-to-clinic translational considerations must be given in determining their efficacy, variables such as the host response, effects on native tissue, and potential for generating tumors. This review will discuss the current knowledge of stem cell research in neurological disease, mainly stroke, with a focus on the benefits, limitations, and clinical potential.
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spelling pubmed-41488192014-08-29 An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside Dailey, Travis Metcalf, Christopher Mosley, Yusef I. Sullivan, Robert Shinozuka, Kazutaka Tajiri, Naoki Pabon, Mibel Acosta, Sandra Kaneko, Yuji van Loveren, Harry Borlongan, Cesar V. J Clin Med Review With a constellation of stem cell sources available, researchers hope to utilize their potential for cellular repair as a therapeutic target for disease. However, many lab-to-clinic translational considerations must be given in determining their efficacy, variables such as the host response, effects on native tissue, and potential for generating tumors. This review will discuss the current knowledge of stem cell research in neurological disease, mainly stroke, with a focus on the benefits, limitations, and clinical potential. MDPI 2013-11-01 /pmc/articles/PMC4148819/ /pubmed/25177494 http://dx.doi.org/10.3390/jcm2040220 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Dailey, Travis
Metcalf, Christopher
Mosley, Yusef I.
Sullivan, Robert
Shinozuka, Kazutaka
Tajiri, Naoki
Pabon, Mibel
Acosta, Sandra
Kaneko, Yuji
van Loveren, Harry
Borlongan, Cesar V.
An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside
title An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside
title_full An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside
title_fullStr An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside
title_full_unstemmed An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside
title_short An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside
title_sort update on translating stem cell therapy for stroke from bench to bedside
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148819/
https://www.ncbi.nlm.nih.gov/pubmed/25177494
http://dx.doi.org/10.3390/jcm2040220
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