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Diagnostic pitfalls of hyperprolactinemia: the importance of sequential pituitary imaging

BACKGROUND: The purpose of this study is to confirm whether the serum prolactin cut-off value is definitive to distinguish prolactinoma and non-functioning pituitary adenoma with hyperprolactinemia. We retrospectively reviewed patients with non-functioning pituitary adenoma, including gonadotroph ce...

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Autores principales: Kawaguchi, Tomohiro, Ogawa, Yoshikazu, Tominaga, Teiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148930/
https://www.ncbi.nlm.nih.gov/pubmed/25142896
http://dx.doi.org/10.1186/1756-0500-7-555
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author Kawaguchi, Tomohiro
Ogawa, Yoshikazu
Tominaga, Teiji
author_facet Kawaguchi, Tomohiro
Ogawa, Yoshikazu
Tominaga, Teiji
author_sort Kawaguchi, Tomohiro
collection PubMed
description BACKGROUND: The purpose of this study is to confirm whether the serum prolactin cut-off value is definitive to distinguish prolactinoma and non-functioning pituitary adenoma with hyperprolactinemia. We retrospectively reviewed patients with non-functioning pituitary adenoma, including gonadotroph cell adenoma, null cell adenoma and prolactinoma who were surgically treated at Kohnan hospital between June 2005 and March 2012. The patients without endocrinological/neurological symptom and with the tumor larger than 40 mm in diameter were excluded. According to previously reported cut-off value of serum prolactin, mild hyperprolactinemia, which is considered non-definitive (border zone) concentration between prolactinoma and non-functioning pituitary adenoma, were defined as 90 – 200 ng/ml. Ninety-five prolactinoma patients and 212 patients with non-functioning pituitary adenoma were analyzed. The serum prolactin concentration, tumor size, and clinical characteristics were statistically compared. RESULTS: Receiver operating characteristic (ROC) curve analysis was performed, indicating that cut-off value of serum prolactin concentration to distinguish between non-functioning pituitary adenoma and prolactinoma was 38.6 ng/ml. Although it was statistically good accuracy (the area under the curve; 0.96, sensitivity; 0.99 and specificity; 0.81), the result did not fit the clinical situation as many false-positive cases (40 of 212, 18.9%) were included. Among them, mild hyperprolactinemia were shown in 9 (4.2%) and 53 (55.8%) non-functioning pituitary adenoma and prolactinoma, respectively. Four of 9 border zone patients with non-functioning pituitary adenoma were initially treated with dopamine agonists. Sequential head magnetic resonance imaging revealed no tumor shrinkage in all of them despite serum prolactin concentration was decreased. Surgery was chosen for them 24.6 months in average after the introduction of medication. CONCLUSIONS: Non-negligible number of patients with non-functioning pituitary adenoma presented unexpectedly high concentration of prolactin, fraught with a potential risk of misdiagnosis. While this equivocal population is not the majority, the prolactin cut-off value is not safely applicable. Especially for the patients with border zone prolactin concentration, meticulous follow up with sequential pituitary imaging is important.
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spelling pubmed-41489302014-08-30 Diagnostic pitfalls of hyperprolactinemia: the importance of sequential pituitary imaging Kawaguchi, Tomohiro Ogawa, Yoshikazu Tominaga, Teiji BMC Res Notes Research Article BACKGROUND: The purpose of this study is to confirm whether the serum prolactin cut-off value is definitive to distinguish prolactinoma and non-functioning pituitary adenoma with hyperprolactinemia. We retrospectively reviewed patients with non-functioning pituitary adenoma, including gonadotroph cell adenoma, null cell adenoma and prolactinoma who were surgically treated at Kohnan hospital between June 2005 and March 2012. The patients without endocrinological/neurological symptom and with the tumor larger than 40 mm in diameter were excluded. According to previously reported cut-off value of serum prolactin, mild hyperprolactinemia, which is considered non-definitive (border zone) concentration between prolactinoma and non-functioning pituitary adenoma, were defined as 90 – 200 ng/ml. Ninety-five prolactinoma patients and 212 patients with non-functioning pituitary adenoma were analyzed. The serum prolactin concentration, tumor size, and clinical characteristics were statistically compared. RESULTS: Receiver operating characteristic (ROC) curve analysis was performed, indicating that cut-off value of serum prolactin concentration to distinguish between non-functioning pituitary adenoma and prolactinoma was 38.6 ng/ml. Although it was statistically good accuracy (the area under the curve; 0.96, sensitivity; 0.99 and specificity; 0.81), the result did not fit the clinical situation as many false-positive cases (40 of 212, 18.9%) were included. Among them, mild hyperprolactinemia were shown in 9 (4.2%) and 53 (55.8%) non-functioning pituitary adenoma and prolactinoma, respectively. Four of 9 border zone patients with non-functioning pituitary adenoma were initially treated with dopamine agonists. Sequential head magnetic resonance imaging revealed no tumor shrinkage in all of them despite serum prolactin concentration was decreased. Surgery was chosen for them 24.6 months in average after the introduction of medication. CONCLUSIONS: Non-negligible number of patients with non-functioning pituitary adenoma presented unexpectedly high concentration of prolactin, fraught with a potential risk of misdiagnosis. While this equivocal population is not the majority, the prolactin cut-off value is not safely applicable. Especially for the patients with border zone prolactin concentration, meticulous follow up with sequential pituitary imaging is important. BioMed Central 2014-08-20 /pmc/articles/PMC4148930/ /pubmed/25142896 http://dx.doi.org/10.1186/1756-0500-7-555 Text en © Kawaguchi et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Kawaguchi, Tomohiro
Ogawa, Yoshikazu
Tominaga, Teiji
Diagnostic pitfalls of hyperprolactinemia: the importance of sequential pituitary imaging
title Diagnostic pitfalls of hyperprolactinemia: the importance of sequential pituitary imaging
title_full Diagnostic pitfalls of hyperprolactinemia: the importance of sequential pituitary imaging
title_fullStr Diagnostic pitfalls of hyperprolactinemia: the importance of sequential pituitary imaging
title_full_unstemmed Diagnostic pitfalls of hyperprolactinemia: the importance of sequential pituitary imaging
title_short Diagnostic pitfalls of hyperprolactinemia: the importance of sequential pituitary imaging
title_sort diagnostic pitfalls of hyperprolactinemia: the importance of sequential pituitary imaging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148930/
https://www.ncbi.nlm.nih.gov/pubmed/25142896
http://dx.doi.org/10.1186/1756-0500-7-555
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