Blood transcript analysis and metastatic recurrent small bowel carcinoid management

BACKGROUND: Detection of neuroendocrine tumor (NET) disease progression is a key issue in determining management. Currently, assessment is by imaging (MRI/CT and Octreoscan®) and plasma Chromogranin A (CgA) measurement. CASE PRESENTATION: We report use of a NET-specific multigene PCR-derived blood t...

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Autores principales: Modlin, Irvin M, Drozdov, Ignat, Bodei, Lisa, Kidd, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148943/
https://www.ncbi.nlm.nih.gov/pubmed/25095873
http://dx.doi.org/10.1186/1471-2407-14-564
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author Modlin, Irvin M
Drozdov, Ignat
Bodei, Lisa
Kidd, Mark
author_facet Modlin, Irvin M
Drozdov, Ignat
Bodei, Lisa
Kidd, Mark
author_sort Modlin, Irvin M
collection PubMed
description BACKGROUND: Detection of neuroendocrine tumor (NET) disease progression is a key issue in determining management. Currently, assessment is by imaging (MRI/CT and Octreoscan®) and plasma Chromogranin A (CgA) measurement. CASE PRESENTATION: We report use of a NET-specific multigene PCR-derived blood transcript signature (NET Index) to assess disease and correlated CgA and gene transcripts with MRI, CT, Octreoscan®, (11)C-5HTP-PET/CT and (68)Ga-DOTA-PET/CT in a patient with NET. CONCLUSIONS: Our results identify limitations in evaluating disease status by CgA and identify that a PCR-based test is more sensitive. Alteration in NET blood gene transcript levels prior to image-based tumor confirmation suggests this parameter may also have utility as an index of therapeutic efficacy.
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spelling pubmed-41489432014-08-30 Blood transcript analysis and metastatic recurrent small bowel carcinoid management Modlin, Irvin M Drozdov, Ignat Bodei, Lisa Kidd, Mark BMC Cancer Case Report BACKGROUND: Detection of neuroendocrine tumor (NET) disease progression is a key issue in determining management. Currently, assessment is by imaging (MRI/CT and Octreoscan®) and plasma Chromogranin A (CgA) measurement. CASE PRESENTATION: We report use of a NET-specific multigene PCR-derived blood transcript signature (NET Index) to assess disease and correlated CgA and gene transcripts with MRI, CT, Octreoscan®, (11)C-5HTP-PET/CT and (68)Ga-DOTA-PET/CT in a patient with NET. CONCLUSIONS: Our results identify limitations in evaluating disease status by CgA and identify that a PCR-based test is more sensitive. Alteration in NET blood gene transcript levels prior to image-based tumor confirmation suggests this parameter may also have utility as an index of therapeutic efficacy. BioMed Central 2014-08-05 /pmc/articles/PMC4148943/ /pubmed/25095873 http://dx.doi.org/10.1186/1471-2407-14-564 Text en © Modlin et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Modlin, Irvin M
Drozdov, Ignat
Bodei, Lisa
Kidd, Mark
Blood transcript analysis and metastatic recurrent small bowel carcinoid management
title Blood transcript analysis and metastatic recurrent small bowel carcinoid management
title_full Blood transcript analysis and metastatic recurrent small bowel carcinoid management
title_fullStr Blood transcript analysis and metastatic recurrent small bowel carcinoid management
title_full_unstemmed Blood transcript analysis and metastatic recurrent small bowel carcinoid management
title_short Blood transcript analysis and metastatic recurrent small bowel carcinoid management
title_sort blood transcript analysis and metastatic recurrent small bowel carcinoid management
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148943/
https://www.ncbi.nlm.nih.gov/pubmed/25095873
http://dx.doi.org/10.1186/1471-2407-14-564
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