High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients

BACKGROUND: Breast cancer is a heterogeneous disease with a highly variable clinical outcome in which both genetic and epigenetic changes have critical roles. We investigated tumor expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in relation with patient survival and tumor relaps...

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Detalles Bibliográficos
Autores principales: Derr, Remco S, van Hoesel, Anneke Q, Benard, Anne, Goossens-Beumer, Inès J, Sajet, Anita, Dekker-Ensink, N Geeske, de Kruijf, Esther M, Bastiaannet, Esther, Smit, Vincent THBM, van de Velde, Cornelis JH, Kuppen, Peter JK
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148956/
https://www.ncbi.nlm.nih.gov/pubmed/25139823
http://dx.doi.org/10.1186/1471-2407-14-604

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